Recombinant Human SOST/Sclerostin Protein, CF | R&D Systems 1406-ST-025/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human SOST/Sclerostin Protein, CF

catalog :

1406-ST-025/CF

quantity :

25 ug

price :

400 USD

citations: 10

Reference
Kurgan N, Baranowski B, Stoikos J, MacNeil A, Fajardo V, Macpherson R, et al. Characterization of sclerostin's response within white adipose tissue to an obesogenic diet at rest and in response to acute exercise in male mice. Front Physiol. 2022;13:1061715 pubmed publisher
Gronbach M, Mitrach F, Moller S, Rother S, Friebe S, Mayr S, et al. A Versatile Macromer-Based Glycosaminoglycan (sHA3) Decorated Biomaterial for Pro-Osteogenic Scavenging of Wnt Antagonists. Pharmaceutics. 2020;12: pubmed publisher
Ohori F, Kitaura H, Marahleh A, Kishikawa A, Ogawa S, Qi J, et al. Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement. J Immunol Res. 2019;2019:9716758 pubmed publisher
Nguyen Yamamoto L, Tanaka K, St Arnaud R, Goltzman D. Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification. JCI Insight. 2019;4: pubmed publisher
Dole N, Mazur C, Acevedo C, Lopez J, Monteiro D, Fowler T, et al. Osteocyte-Intrinsic TGF-? Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling. Cell Rep. 2017;21:2585-2596 pubmed publisher
Shu R, Bai D, Sheu T, He Y, Yang X, Xue C, et al. Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement. PLoS ONE. 2017;12:e0167312 pubmed publisher
Kogawa M, Wijenayaka A, Ormsby R, Thomas G, Anderson P, Bonewald L, et al. Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2. J Bone Miner Res. 2013;28:2436-48 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Appel H, Ruiz Heiland G, Listing J, Zwerina J, Herrmann M, Mueller R, et al. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum. 2009;60:3257-62 pubmed publisher
Jager A, Gotz W, Lossdörfer S, Rath Deschner B. Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro. J Periodontal Res. 2010;45:246-54 pubmed publisher

product information

master code :

1406-ST/CF

SKU :

1406-ST-025/CF

product name :

Recombinant Human SOST/Sclerostin Protein, CF

unit size :

25 ug

description :

The Recombinant Human SOST/Sclerostin Protein, CF from R&D Systems is derived from NS0. The Recombinant Human SOST/Sclerostin Protein, CF has been validated for the following applications: Bioactivity.

target :

SOST/Sclerostin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

28-32 kDa, reducing conditions

theoretical molecular weight :

22.5 kDa

gene symbol :

SOST

details of functionality :

Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 1.5-6 ╡g/mL in the presence of 3 ng/mL Recombinant Mouse Wnt-3a (Catalog # 1324-WN ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9BQB4

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human SOST/Sclerostin protein Gln24-Tyr213, with an N-terminal 7-His tag

source short :

NS0

USD :

400 USD

alt names :

sclerostin, VBCHsclerosteosis

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.