Recombinant Human IL-23R Fc Chimera Protein, CF | R&D Systems 1400-IR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-23R Fc Chimera Protein, CF

catalog :

1400-IR

quantity :

50 ug

price :

349 USD

citations: 3

Reference
Yu R, Gallagher G. A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells. J Immunol. 2010;185:7302-8 pubmed publisher
Mabry R, Lewis K, Moore M, McKernan P, Bukowski T, Bontadelli K, et al. Engineering of stable bispecific antibodies targeting IL-17A and IL-23. Protein Eng Des Sel. 2010;23:115-27 pubmed publisher
Vaknin Dembinsky A, Balashov K, Weiner H. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol. 2006;176:7768-74 pubmed

product information

brand :

R&D Systems

master code :

1400-IR

SKU :

1400-IR-050

product name :

Recombinant Human IL-23R Fc Chimera Protein, CF

description :

The Recombinant Human IL-23R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-23R Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-23R

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

95-105 kDa, reducing conditions

theoretical molecular weight :

64 kDa (monomer)

gene symbol :

IL23R

details of functionality :

Measured by its ability to inhibit IL-23 induced IL-17 secretion by mouse splenocytes. The ED50 for this effect is 0.008-0.04 µg/mL in the presence of 0.3 ng/mL of rhIL-23.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

1400-IR

accessionNumbers :

Q5VWK5

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human IL-23 R protein Human IL-23 R (Gly24 - Asp353) Accession # Q5VWK5 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

2020 USD :

349

2021 USD :

349 USD

alt names :

IBD17, IL-23 R, IL-23 receptor, IL23R, IL-23R, interleukin 23 receptor, interleukin-23 receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.