product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-23R Fc Chimera Protein, CF
catalog :
1400-IR-050
quantity :
50 ug
price :
405 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Roberts K, Cubitt M, Carlton T, Rodrigues Duarte L, Maggiore L, Chai R, et al. Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease. Sci Rep. 2021;11:19422 pubmed publisher
Liu D, Xing S, Wang W, Huang X, Lin H, Chen Y, et al. Prognostic value of serum soluble interleukin-23 receptor and related T-helper 17 cell cytokines in non-small cell lung carcinoma. Cancer Sci. 2020;111:1093-1102 pubmed publisher
Yu R, Gallagher G. A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells. J Immunol. 2010;185:7302-8 pubmed publisher
Vaknin Dembinsky A, Balashov K, Weiner H. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol. 2006;176:7768-74 pubmed
product information
brand :
R&D Systems
master code :
1400-IR
SKU :
1400-IR-050
product name :
Recombinant Human IL-23R Fc Chimera Protein, CF
description :
The Recombinant Human IL-23R Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-23R Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-23R
category :
Proteins and Enzymes
sizes available :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
95-105 kDa, reducing conditions
theoretical molecular weight :
64 kDa (monomer)
gene symbol :
IL23R
details of functionality :
Measured by its ability to inhibit IL-23 induced IL-17 secretion by mouse splenocytes. The ED50 for this effect is 0.008-0.04 µg/mL in the presence of 0.3 ng/mL of rhIL-23.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q5VWK5
applications :
Bioactivity
source :
NS0-derived Recombinant Human IL-23R Fc Chimera Protein, CF
USD :
399
USD 2023 :
405 USD
alt names :
IBD17, IL-23 R, IL-23 receptor, IL23R, IL-23R, interleukin 23 receptor, interleukin-23 receptor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.