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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TSLP Protein
catalog :
1398-TS-010
quantity :
10 ug
price :
388 USD
more info or order :
citations: 42
Reference
Yu C, Huang W, Zhou Z, Liang S, Zhou Z, Liu J, et al. Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin. Respir Res. 2022;23:75 pubmed publisher
Bonam S, Chauvin C, Mathew M, Bayry J. IFN-γ Induces PD-L1 Expression in Primed Human Basophils. Cells. 2022;11: pubmed publisher
Thomas K, Allenspach E, Camp N, Wray Dutra M, Khim S, Zielinska Kwiatkowska A, et al. Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice. Leukemia. 2022;36:42-57 pubmed publisher
Petrova T, Pesic J, Pardali K, Gaestel M, Arthur J. p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells. Sci Rep. 2020;10:3479 pubmed publisher
Ogasawara N, Poposki J, Klingler A, Tan B, Hulse K, Stevens W, et al. Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps. Mucosal Immunol. 2020;13:86-95 pubmed publisher
Ragonnaud E, Moritoh K, Bodogai M, Gusev F, Garaud S, Chen C, et al. Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis. Cancer Res. 2019;79:5826-5838 pubmed publisher
Hochdörfer T, Winkler C, Pardali K, Mjösberg J. Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells. Eur J Immunol. 2019;49:884-893 pubmed publisher
Yang H, Chang K, Mei J, Zhou W, Liu L, Yao L, et al. Estrogen restricts the apoptosis of endometrial stromal cells by promoting TSLP secretion. Mol Med Rep. 2018;18:4410-4416 pubmed publisher
Zhang B, Wei C, Chang K, Yu J, Zhou W, Yang H, et al. TSLP promotes angiogenesis of human umbilical vein endothelial cells by strengthening the crosstalk between cervical cancer cells and eosinophils. Oncol Lett. 2017;14:7483-7488 pubmed publisher
Orellana A, García González V, Lopez R, Pascual Guiral S, Lozoya E, Diaz J, et al. Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells. PLoS ONE. 2018;13:e0189247 pubmed publisher
Camelo A, Rosignoli G, Ohne Y, Stewart R, Overed Sayer C, Sleeman M, et al. IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells. Blood Adv. 2017;1:577-589 pubmed publisher
Schroeder J, Bieneman A. Activation of Human Basophils by A549 Lung Epithelial Cells Reveals a Novel IgE-Dependent Response Independent of Allergen. J Immunol. 2017;199:855-865 pubmed publisher
Peng Y, Meng K, Jiang L, Zhong Y, Yang Y, Lan Y, et al. Thymic stromal lymphopoietin-induced HOTAIR activation promotes endothelial cell proliferation and migration in atherosclerosis. Biosci Rep. 2017;37: pubmed publisher
Lombardi V, Luce S, Moussu H, Morizur L, Gueguen C, Neukirch C, et al. Effector and regulatory dendritic cells display distinct patterns of miRNA expression. Immun Inflamm Dis. 2017;5:310-317 pubmed publisher
Poposki J, Klingler A, Tan B, Soroosh P, Banie H, Lewis G, et al. Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps. Immun Inflamm Dis. 2017;5:233-243 pubmed publisher
Chiu C, Su S, Fan W, Lai S, Tsai M, Chen S, et al. Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption. Sci Rep. 2017;7:43469 pubmed publisher
Dong H, Hu Y, Liu L, Zou M, Huang C, Luo L, et al. Distinct roles of short and long thymic stromal lymphopoietin isoforms in house dust mite-induced asthmatic airway epithelial barrier disruption. Sci Rep. 2016;6:39559 pubmed publisher
Lévy R, Okada S, Béziat V, Moriya K, Liu C, Chai L, et al. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency. Proc Natl Acad Sci U S A. 2016;113:E8277-E8285 pubmed publisher
Haas J, Schwarz A, Korporal Kuhnke M, Jarius S, Wildemann B. Myeloid dendritic cells exhibit defects in activation and function in patients with multiple sclerosis. J Neuroimmunol. 2016;301:53-60 pubmed publisher
Takahashi N, Sugaya M, Suga H, Oka T, Kawaguchi M, Miyagaki T, et al. Thymic Stromal Chemokine TSLP Acts through Th2 Cytokine Production to Induce Cutaneous T-cell Lymphoma. Cancer Res. 2016;76:6241-6252 pubmed
Bal S, Bernink J, Nagasawa M, Groot J, Shikhagaie M, Golebski K, et al. IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs. Nat Immunol. 2016;17:636-45 pubmed publisher
Shin J, Kim S, Kim H, Noh J, Jin S, Park C, et al. TSLP Is a Potential Initiator of Collagen Synthesis and an Activator of CXCR4/SDF-1 Axis in Keloid Pathogenesis. J Invest Dermatol. 2016;136:507-515 pubmed publisher
Biancheri P, Di Sabatino A, Rescigno M, Giuffrida P, Fornasa G, Tsilingiri K, et al. Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease. Gut. 2016;65:1670-80 pubmed publisher
Hillen M, Hartgring S, Willis C, Radstake T, Hack C, Lafeber F, et al. The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade. PLoS ONE. 2015;10:e0130830 pubmed publisher
Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, et al. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med. 2015;212:619-31 pubmed publisher
Nino G, Huseni S, Perez G, Pancham K, Mubeen H, Abbasi A, et al. Directional secretory response of double stranded RNA-induced thymic stromal lymphopoetin (TSLP) and CCL11/eotaxin-1 in human asthmatic airways. PLoS ONE. 2014;9:e115398 pubmed publisher
Kubo T, Kamekura R, Kumagai A, Kawata K, Yamashita K, Mitsuhashi Y, et al. ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis. PLoS ONE. 2014;9:e105498 pubmed publisher
Melum G, Farkas L, Scheel C, Van Dieren B, Gran E, Liu Y, et al. A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa. J Allergy Clin Immunol. 2014;134:613-621.e7 pubmed publisher
Volpe E, Pattarini L, Martinez Cingolani C, Meller S, Donnadieu M, Bogiatzi S, et al. Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol. 2014;134:373-81 pubmed publisher
Maddur M, Sharma M, Hegde P, Stephen Victor E, Pulendran B, Kaveri S, et al. Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand. Nat Commun. 2014;5:4092 pubmed publisher
Morshed M, Hlushchuk R, Simon D, Walls A, Obata Ninomiya K, Karasuyama H, et al. NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014;192:5314-23 pubmed publisher
Teunissen M, Munneke J, Bernink J, Spuls P, Res P, te Velde A, et al. Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol. 2014;134:2351-2360 pubmed publisher
Du M, Guo P, Piao H, Wang S, Sun C, Jin L, et al. Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells. J Immunol. 2014;192:1502-11 pubmed publisher
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 2012;10:e1001395 pubmed publisher
Barin J, Baldeviano G, Talor M, Wu L, Ong S, Quader F, et al. Macrophages participate in IL-17-mediated inflammation. Eur J Immunol. 2012;42:726-36 pubmed publisher
Hvid M, Vestergaard C, Kemp K, Christensen G, Deleuran B, Deleuran M. IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?. J Invest Dermatol. 2011;131:150-7 pubmed publisher
Semlali A, Jacques E, Koussih L, Gounni A, Chakir J. Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway. J Allergy Clin Immunol. 2010;125:844-50 pubmed publisher
Zheng X, Ma P, de Paiva C, Cunningham M, Hwang C, Pflugfelder S, et al. TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2010;51:3076-82 pubmed publisher
Okayama Y, Okumura S, Sagara H, Yuki K, Sasaki T, Watanabe N, et al. FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells. Eur Respir J. 2009;34:425-35 pubmed publisher
Yokoi T, Amakawa R, Tanijiri T, Sugimoto H, Torii Y, Amuro H, et al. Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol. 2008;20:1321-9 pubmed publisher
Spiegl N, Didichenko S, McCaffery P, Langen H, Dahinden C. Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid. Blood. 2008;112:3762-71 pubmed publisher
Seshasayee D, Lee W, Zhou M, Shu J, Suto E, Zhang J, et al. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J Clin Invest. 2007;117:3868-78 pubmed
image
image 1 :
R&D Systems 1398-TS-010 image 1
Recombinant Human TSLP Protein Bioactivity
product information
brand :
R&D Systems
master code :
1398-TS
SKU :
1398-TS-010
product name :
Recombinant Human TSLP Protein
unit size :
10 ug
description :
The Recombinant Human TSLP Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human TSLP Protein, CF has been validated for the following applications: Bioactivity.
target :
TSLP
category :
Proteins and Enzymes
alt names :
thymic stromal lymphopoietin
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
all available conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
theoretical molecular weight :
15 kDa
gene symbol :
TSLP
details of functionality :
Measured in a cell proliferation assay using BaF3 mouse pro-B cells co-transfected with human IL-7 R alpha and human TSLP R. Reche, P.A. et al . (2001) J. Immunol. 167 :336. The ED50 for this effect is 0.05-0.3 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q969D9.1
applications :
Bioactivity
source :
E. coli-derived Recombinant Human TSLP Protein
USD :
359
Jul-22 :
388 USD
sizes available :
10 ug
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.