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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse NKG2D Fc Chimera Protein, CF
catalog :
139-NK-050
quantity :
50 ug
price :
456 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
Badrinath S, Dellacherie M, Li A, Zheng S, Zhang X, Sobral M, et al. A vaccine targeting resistant tumours by dual T cell plus NK cell attack. Nature. 2022;606:992-998 pubmed publisher
Alsahafi N, Richard J, Prévost J, Coutu M, Brassard N, Parsons M, et al. Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity. J Virol. 2017;91: pubmed publisher
Li Y, Liu M, Zuo Z, Liu J, Yu X, Guan Y, et al. TLR9 Regulates the NF-?B-NLRP3-IL-1? Pathway Negatively in Salmonella-Induced NKG2D-Mediated Intestinal Inflammation. J Immunol. 2017;199:761-773 pubmed publisher
Isernhagen A, Malzahn D, Viktorova E, Elsner L, Monecke S, von Bonin F, et al. The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation. EMBO Mol Med. 2015;7:1480-502 pubmed publisher
Vanseggelen H, Hammill J, Dvorkin Gheva A, Tantalo D, Kwiecien J, Denisova G, et al. T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice. Mol Ther. 2015;23:1600-10 pubmed publisher
Tougaard P, Skov S, Pedersen A, Krych L, Nielsen D, Bahl M, et al. TL1A regulates TCRγδ+ intraepithelial lymphocytes and gut microbial composition. Eur J Immunol. 2015;45:865-75 pubmed publisher
Lin Z, Wang C, Xia H, Liu W, Xiao W, Qian L, et al. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1? transgenic mice. Immunology. 2014;141:401-15 pubmed publisher
Lacotte S, Oldani G, Slits F, Orci L, Rubbia Brandt L, Morel P, et al. Alloimmune activation promotes anti-cancer cytotoxicity after rat liver transplantation. PLoS ONE. 2014;9:e91515 pubmed publisher
Tietje A, Li J, Yu X, Wei Y. MULT1E/mIL-12: a novel bifunctional protein for natural killer cell activation. Gene Ther. 2014;21:468-75 pubmed publisher
Rothe A, Jachimowicz R, Borchmann S, Madlener M, Keßler J, Reiners K, et al. The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma. Int J Cancer. 2014;134:2829-40 pubmed publisher
Yoshida S, Mohamed R, Kajikawa M, Koizumi J, Tanaka M, Fugo K, et al. Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. J Immunol. 2012;188:3972-9 pubmed publisher
Dong Z, Cruz Munoz M, Zhong M, Chen R, Latour S, Veillette A. Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Nat Immunol. 2009;10:973-80 pubmed publisher
Dibra D, Cutrera J, Xia X, Birkenbach M, Li S. Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance. Cancer Res. 2009;69:5505-13 pubmed publisher
Kwong K, Baskar S, Zhang H, Mackall C, Rader C. Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity. J Mol Biol. 2008;384:1143-56 pubmed publisher
Kotturi H, Li J, Branham O Connor M, Stickel S, Yu X, Wagner T, et al. Tumor cells expressing a fusion protein of MULT1 and Fas are rejected in vivo by apoptosis and NK cell activation. Gene Ther. 2008;15:1302-10 pubmed publisher
Unni A, Bondar T, Medzhitov R. Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A. 2008;105:1686-91 pubmed publisher
Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, et al. Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J Immunol. 2008;180:1678-85 pubmed
Barber A, Zhang T, Demars L, Conejo Garcia J, Roby K, Sentman C. Chimeric NKG2D receptor-bearing T cells as immunotherapy for ovarian cancer. Cancer Res. 2007;67:5003-8 pubmed
Zhou H, Luo Y, Lo J, Kaplan C, Mizutani M, Mizutani N, et al. DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the NKG2D receptor. Proc Natl Acad Sci U S A. 2005;102:10846-51 pubmed
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
139-NK
SKU :
139-NK-050
product name :
Recombinant Mouse NKG2D Fc Chimera Protein, CF
description :
The Recombinant Mouse NKG2D Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse NKG2D Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
NKG2D/CD314
unit size :
50 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>85%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
55-60 kDa, reducing conditions
theoretical molecular weight :
42.7 kDa (monomer)
gene symbol :
Klrk1
details of functionality :
Measured by its binding ability in a functional ELISA. Immobilized rmNKG2D/Fc Chimera at 4 µg/mL (100 µL/well) can bind biotinylated rmRae-1 gamma /Fc Chimera with a linear range of 1.56-100 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q4FJM0
applications :
Binding Activity
product keywords :
139-NK, rmNKG2D/Fc, mNKG2D, carrier-free, carrier free, 139NK, NK cells, NKG2 D, Killer Cell Lectin Like Receptor K1, NKG2-D Type II Integral Membrane Protein, NKG2-D-Activating NK Receptor, NK Cell Receptor D, D12S2489E, KLR, NKG2-D, CD314 Antigen, DNA Segment On Chromosome 12 (Unique) 2489 Expressed Sequence
source :
NS0-derived Recombinant Mouse NKG2D Fc Chimera Protein, CF
USD :
447
USD 2025 :
456 USD
alt names :
CD314, CD314 antigen, D12S2489E, FLJ17759, FLJ75772, Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K, member 1, KLR, KLRK1, NK cell receptor D, NKG2-D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2DDNA segment on chromosome 12 (unique) 2489 expressed sequence
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.