product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse DLL4 His-tag Protein, CF
catalog :
1389-D4-050/CF
quantity :
50 ug
price :
394 USD
more info or order :
R&D Systems product webpage
citations: 19
Reference
Cha S, Yu X, Gregory B, Lee Y, Ishino T, Opoka R, et al. Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways. MBio. 2022;13:e0370821 pubmed publisher
Kakuda S, LoPilato R, Ito A, Haltiwanger R. Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. J Biol Chem. 2020;295:14710-14722 pubmed publisher
Lin J, Hu J, Schlotterer A, Wang J, Kolibabka M, Awwad K, et al. Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease. Theranostics. 2020;10:7857-7871 pubmed publisher
Fu R, Lv W, Xu Y, Gong M, Chen X, Jiang N, et al. Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. Nat Commun. 2020;11:460 pubmed publisher
Silkenstedt E, Arenas F, Colom Sanmartí B, Xargay Torrent S, Higashi M, Giró A, et al. Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy. J Exp Clin Cancer Res. 2019;38:446 pubmed publisher
Gerli M, Moyle L, Benedetti S, Ferrari G, Ucuncu E, Ragazzi M, et al. Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells. Stem Cell Reports. 2019;12:461-473 pubmed publisher
Liu L, Charville G, Cheung T, Yoo B, Santos P, Schroeder M, et al. Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells. Cell Stem Cell. 2018;23:544-556.e4 pubmed publisher
Ting H, de Almeida Nagata D, Rasky A, Malinczak C, Maillard I, Schaller M, et al. Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection. Mucosal Immunol. 2018;11:1524-1536 pubmed publisher
Yuyun X, Xi C, Qing Y, Lin X, Ke R, Bingwei S. Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathway. Oncotarget. 2018;9:15036-15046 pubmed publisher
Kostrzewski T, Borg A, Meng Y, Filipovic I, Male V, Wack A, et al. Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development. J Immunol. 2018;200:1370-1381 pubmed publisher
Suzuki H, Ahuja C, Salewski R, Li L, Satkunendrarajah K, Nagoshi N, et al. Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury. PLoS ONE. 2017;12:e0182339 pubmed publisher
Yu V, Saez B, Cook C, Lotinun S, Pardo Saganta A, Wang Y, et al. Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. J Exp Med. 2015;212:759-74 pubmed publisher
Ohnuki H, Jiang K, Wang D, Salvucci O, Kwak H, Sánchez Martín D, et al. Tumor-infiltrating myeloid cells activate Dll4/Notch/TGF-β signaling to drive malignant progression. Cancer Res. 2014;74:2038-49 pubmed publisher
Hu J, Popp R, Frömel T, Ehling M, Awwad K, Adams R, et al. Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med. 2014;211:281-95 pubmed publisher
Cappellari O, Benedetti S, Innocenzi A, Tedesco F, Moreno Fortuny A, Ugarte G, et al. Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory. Dev Cell. 2013;24:586-99 pubmed publisher
Benedito R, Rocha S, Woeste M, Zamykal M, Radtke F, Casanovas O, et al. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature. 2012;484:110-4 pubmed publisher
Haller B, Brave A, Wallgard E, Roswall P, Sunkari V, Mattson U, et al. Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma. Oncogene. 2010;29:4276-86 pubmed publisher
Oya S, Yoshikawa G, Takai K, Tanaka J, Higashiyama S, Saito N, et al. Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury. Neuroscience. 2009;158:683-92 pubmed publisher
Carlson M, Hsu M, Conboy I. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature. 2008;454:528-32 pubmed publisher
product information
brand :
R&D Systems
master code :
1389-D4/CF
SKU :
1389-D4-050/CF
product name :
Recombinant Mouse DLL4 His-tag Protein, CF
description :
The Recombinant Mouse DLL4 His-tag Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse DLL4 His-tag Protein, CF has been validated for the following applications: Bioactivity.
target :
DLL4
category :
Proteins and Enzymes
sizes available :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Tris-HCl, NaCl and PEG3350.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
observed molecular weight :
75-80 kDa, reducing conditions
theoretical molecular weight :
55.6 kDa
gene symbol :
Dll4
details of functionality :
Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 150-600 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
BAB18580
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse DLL4 His-tag Protein, CF
USD :
388
USD 2023 :
394 USD
alt names :
delta 4, Delta 4 precursor, delta ligand 4, delta4, delta-like 4 (Drosophila), delta-like 4 homolog, delta-like 4 homolog (Drosophila), delta-like 4 protein, delta-like protein 4, Drosophila Delta homolog 4, hdelta2, MGC126344, notch ligand delta-2, notch ligand DLL4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.