Recombinant Human N-Cadherin Fc Chimera Protein, CF | R&D Systems 1388-NC-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human N-Cadherin Fc Chimera Protein, CF

catalog :

1388-NC-050

quantity :

50 ug

price :

432 USD

citations: 12

Reference
Kim D, Olson J, Cooper J. N-cadherin dynamically regulates pediatric glioma cell migration in complex environments. bioRxiv. 2024;: pubmed publisher
Micalizzi D, Che D, Nicholson B, Edd J, Desai N, Lang E, et al. Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody. Proc Natl Acad Sci U S A. 2022;119:e2209563119 pubmed publisher
Khorsand M, Khajeh S, Eslami M, Nezafat N, Ghasemi Y, Razban V, et al. Telmisartan anti-cancer activities mechanism through targeting N-cadherin by mimicking ADH-1 function. J Cell Mol Med. 2022;26:2392-2403 pubmed publisher
Schinner C, Erber B, Yeruva S, Schlipp A, Rötzer V, Kempf E, et al. Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy. JCI Insight. 2020;5: pubmed publisher
Monzel C, Becker A, Saffrich R, Wuchter P, Eckstein V, Ho A, et al. Dynamic cellular phynotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents. Sci Rep. 2018;8:1841 pubmed publisher
Sun Z, Li M, Li Z, Hill M, Meininger G. N-Cadherin, a novel and rapidly remodelling site involved in vasoregulation of small cerebral arteries. J Physiol. 2017;595:1987-2000 pubmed publisher
Parnaud G, Lavallard V, Bédat B, Matthey Doret D, Morel P, Berney T, et al. Cadherin engagement improves insulin secretion of single human β-cells. Diabetes. 2015;64:887-96 pubmed publisher
Guan X, Bartlett J. MMP20 modulates cadherin expression in ameloblasts as enamel develops. J Dent Res. 2013;92:1123-8 pubmed publisher
Oblander S, Brady Kalnay S. Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin. Mol Cell Neurosci. 2010;44:78-93 pubmed publisher
Pittet P, Lee K, Kulik A, Meister J, Hinz B. Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds. J Cell Sci. 2008;121:877-86 pubmed publisher
Isakova I, Baker K, DuTreil M, Dufour J, Gaupp D, Phinney D. Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells. 2007;25:3261-70 pubmed
Oblander S, Ensslen Craig S, Longo F, Brady Kalnay S. E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner. Mol Cell Neurosci. 2007;34:481-92 pubmed

product information

master code :

1388-NC

SKU :

1388-NC-050

product name :

Recombinant Human N-Cadherin Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human N-Cadherin Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human N-Cadherin Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

N-Cadherin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris-Citrate.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

115-130 kDa, reducing conditions

theoretical molecular weight :

89.2 kDa (monomer)

gene symbol :

CDH2

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of U-118-MG human glioblastoma/astrocytoma cells. Recombinant Human N-Cadherin Fc Chimera immobilized at 10 ╡g/mL, 100 ╡L/well, will induce =55% cell adhesion. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P19022.4

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human N-Cadherin protein Human N-Cadherin Asp160-Ala724 Accession # P19022.4 IEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

extended description :

Analyzed by SEC-MALS

USD :

432 USD

product details :

Analyzed by SEC-MALS

alt names :

ACOGS, ARVD14, cadherin 2, type 1, N-cadherin (neuronal), cadherin-2, calcium-dependent adhesion protein, neuronal, CD325, CD325 antigen, CDH2, CDHN, CDw325, NCAD, N-cadherin, NCadherin, N-cadherin 1, Neural cadherin, neural-cadherin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.