This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Granzyme H Protein, CF
catalog :
1377-SE
quantity :
10 ug
price :
359 USD
citations: 2
Reference
Larimer B, Wehrenberg Klee E, Dubois F, Mehta A, Kalomeris T, Flaherty K, et al. Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response. Cancer Res. 2017;77:2318-2327 pubmed publisher
Fellows E, Gil Parrado S, Jenne D, Kurschus F. Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program. Blood. 2007;110:544-52 pubmed
product information
brand :
R&D Systems
master code :
1377-SE
SKU :
1377-SE-010
product name :
Recombinant Human Granzyme H Protein, CF
description :
The Recombinant Human Granzyme H Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Granzyme H Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Granzyme H
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Supplied as a 0.2 µm filtered solution in HEPES, NaCl and Brij-35.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
Multiple bands between 38-40 kDa, reducing conditions
theoretical molecular weight :
27 kDa
gene symbol :
GZMH
details of functionality :
Measured by its ability to cleave a peptide substrate, Succinyl-Phe-Leu-Phe-ThioBenzyl ester (Suc-FLF-SBzl), in the presence of 5,5’-Dithio-bis (2-nitrobenzoic acid) (DTNB). Edwards, K.M. et al . (1999) J. Biol. Chem. 274 :30468. The specific activity is 5,000 pmol/min/µg, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
1377-SE
accessionNumbers :
P20718
applications :
Enzyme Activity
source :
Mouse myeloma cell line, NS0-derived human Granzyme H protein Glu19-Leu246, with a C-terminal 10-His tag Accession # P20718
2020 USD :
359
2021 USD :
359 USD
alt names :
Cathepsin G-like 2, CCP-X, CCP-Xcytotoxic T-lymphocyte-associated serine esterase 1, CGL2, CGL-2, CSP-Ccytotoxin serine protease-C, CTLA1, CTSGL2, CTSGL2granzyme H, Cytotoxic serine protease C, Cytotoxic T-lymphocyte proteinase, EC 3.4.21, EC 3.4.21.-, EC 3.4.21.79, granzyme H (cathepsin G-like 2, protein h-CCPX), GrzH, GZMH
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.