Recombinant Human Granzyme H Protein, CF | R&D Systems 1377-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Granzyme H Protein, CF

catalog :

1377-SE-010

quantity :

10 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Larimer B, Wehrenberg Klee E, Dubois F, Mehta A, Kalomeris T, Flaherty K, et al. Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response. Cancer Res. 2017;77:2318-2327 pubmed publisher
Fellows E, Gil Parrado S, Jenne D, Kurschus F. Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program. Blood. 2007;110:544-52 pubmed

product information

master code :

1377-SE

SKU :

1377-SE-010

product name :

Recombinant Human Granzyme H Protein, CF

unit size :

10 ug

description :

The Recombinant Human Granzyme H Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Granzyme H Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Granzyme H

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in HEPES, NaCl and Brij-35.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

Multiple bands between 38-40 kDa, reducing conditions

theoretical molecular weight :

27 kDa

gene symbol :

GZMH

details of functionality :

Measured by its ability to cleave a peptide substrate, Succinyl-Phe-Leu-Phe-ThioBenzyl ester (Suc-FLF-SBzl), in the presence of 5,5Æ-Dithio-bis (2-nitrobenzoic acid) (DTNB). Edwards, K.M. et al . (1999) J. Biol. Chem. 274 :30468. The specific activity is 5,000 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P20718

applications :

Enzyme Activity

source long :

Mouse myeloma cell line, NS0-derived human Granzyme H protein Glu19-Leu246, with a C-terminal 10-His tag Accession # P20718

source short :

NS0

USD :

456 USD

alt names :

Cathepsin G-like 2, CCP-X, CCP-Xcytotoxic T-lymphocyte-associated serine esterase 1, CGL2, CGL-2, CSP-Ccytotoxin serine protease-C, CTLA1, CTSGL2, CTSGL2granzyme H, Cytotoxic serine protease C, Cytotoxic T-lymphocyte proteinase, EC 3.4.21, EC 3.4.21.-, EC 3.4.21.79, granzyme H (cathepsin G-like 2, protein h-CCPX), GrzH, GZMH

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage