product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human WIF-1 Protein
catalog :
1341-WF-050
quantity :
50 ug
price :
394 USD
more info or order :
R&D Systems product webpage
citations: 14
Reference
Zhang N, Lin J, Chin J, Wiraja C, Xu C, McGrouther D, et al. Delivery of Wnt inhibitor WIF1 via engineered polymeric microspheres promotes nerve regeneration after sciatic nerve crush. J Tissue Eng. 2022;13:20417314221087417 pubmed publisher
Kerekes K, Trexler M, Banyai L, Patthy L. Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog. Cells. 2021;10: pubmed publisher
Pettinato G, Coughlan M, Zhang X, Chen L, Khan U, Glyavina M, et al. Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids. Sci Adv. 2021;7: pubmed publisher
Pettinato G, Lehoux S, Ramanathan R, Salem M, He L, Muse O, et al. Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells. Sci Rep. 2019;9:8920 pubmed publisher
Pan S, Deng Y, Fu J, Zhang Y, Zhang Z, Ru X, et al. Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling. Cell Physiol Biochem. 2018;46:2138-2148 pubmed publisher
Skaria T, Bächli E, Schoedon G. WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells. J Inflamm (Lond). 2017;14:10 pubmed publisher
Pettinato G, Ramanathan R, Fisher R, Mangino M, Zhang N, Wen X. Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/?-catenin Pathway Inhibition. Sci Rep. 2016;6:32888 pubmed publisher
Skaria T, Burgener J, Bächli E, Schoedon G. IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling. PLoS ONE. 2016;11:e0156002 pubmed publisher
Skaria T, Bächli E, Schoedon G. Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells. Cell Adh Migr. 2017;11:24-38 pubmed publisher
Tsakiridis A, Huang Y, Blin G, Skylaki S, Wymeersch F, Osorno R, et al. Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors. Development. 2014;141:1209-21 pubmed publisher
Keil K, Mehta V, Branam A, Abler L, Buresh Stiemke R, Joshi P, et al. Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development. Endocrinology. 2012;153:6091-103 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Gudjonsson J, Johnston A, Stoll S, Riblett M, Xing X, Kochkodan J, et al. Evidence for altered Wnt signaling in psoriatic skin. J Invest Dermatol. 2010;130:1849-59 pubmed publisher
Cho S, Yang J, Sun H, Jung J, Her S, Cho H, et al. Wnt inhibitory factor (WIF)-1 inhibits osteoblastic differentiation in mouse embryonic mesenchymal cells. Bone. 2009;44:1069-77 pubmed publisher
product information
brand :
R&D Systems
master code :
1341-WF
SKU :
1341-WF-050
product name :
Recombinant Human WIF-1 Protein
description :
The Recombinant Human WIF-1 Protein from R&D Systems is derived from NS0. The Recombinant Human WIF-1 Protein has been validated for the following applications: Bioactivity.
target :
WIF-1
category :
Proteins and Enzymes
sizes available :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetic Acid, NaCl, PEG3350 and CHAPS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
50 kDa, reducing conditions
theoretical molecular weight :
39.8 kDa
gene symbol :
WIF1
details of functionality :
Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.3-1.5 µg/mL in the presence of 10 ng/mL of Wnt-3a.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAD25402
applications :
Bioactivity
source :
NS0-derived Recombinant Human WIF-1 Protein
USD :
388
USD 2023 :
394 USD
alt names :
WIF1, WIF-1, WNT inhibitory factor 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.