Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF | R&D Systems 1330-CD-050/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF

catalog :

1330-CD-050/CF

quantity :

50 ug (also 1 mg)

price :

443 USD

citations: 14

Reference
Vanhove B, Duvaux O, Rousse J, Royer P, Evanno G, Ciron C, et al. High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2. Eur J Immunol. 2021;51:1412-1422 pubmed publisher
Zekri L, Vogt F, Osburg L, M xfc ller S, Kauer J, Manz T, et al. An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer. EMBO Mol Med. 2021;13:e11902 pubmed publisher
Blundell P, Lu D, Wilkinson M, Dell A, Haslam S, Pleass R. Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus. J Immunol. 2019;202:1595-1611 pubmed publisher
Oshima T, Miyashita H, Ishimura Y, Ito Y, Tanaka Y, Hori A, et al. Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey. PLoS ONE. 2018;13:e0196422 pubmed publisher
Gabriel M, Adomeh D, Ehimuan J, Oyakhilome J, Omomoh E, Ighodalo Y, et al. Development and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G. PLoS Negl Trop Dis. 2018;12:e0006361 pubmed publisher
Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
Seo N, Polozova A, Zhang M, Yates Z, Cao S, Li H, et al. Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab. MAbs. 2018;10:678-691 pubmed publisher
Järnum S, Runström A, Bockermann R, Winstedt L, Crispin M, Kjellman C. Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy. Mol Cancer Ther. 2017;16:1887-1897 pubmed publisher
Zhang X, Olsen H, Chen S, So E, Zhou H, Burch E, et al. Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease. J Immunol. 2016;196:1165-76 pubmed publisher
Ito K, Sakai K, Suzuki Y, Ozawa N, Hatta T, Natsume T, et al. Artificial human Met agonists based on macrocycle scaffolds. Nat Commun. 2015;6:6373 pubmed publisher
Meuris L, Santens F, Elson G, Festjens N, Boone M, Dos Santos A, et al. GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins. Nat Biotechnol. 2014;32:485-9 pubmed publisher
Xie J, Yamniuk A, Borowski V, Kuhn R, Susulic V, Rex Rabe S, et al. Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases. J Immunol. 2014;192:4083-92 pubmed publisher
Bergin D, Reeves E, Meleady P, Henry M, McElvaney O, Carroll T, et al. ?-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. J Clin Invest. 2010;120:4236-50 pubmed publisher
Shanmugarajan S, Beeson C, Reddy S. Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation. Endocrinology. 2010;151:4389-99 pubmed publisher

product information

master code :

1330-CD/CF

SKU :

1330-CD-050/CF

product name :

Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF

unit size :

50 ug (also 1 mg)

description :

The Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF has been validated for the following applications: Binding Activity.

target :

Fc gamma RIIA/CD32a

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

26-36 kDa, under reducing conditions.

theoretical molecular weight :

22 kDa

gene symbol :

FCGR2A

details of functionality :

Measured by its ability to bind human IgG with an estimated Kd 80 nM.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human Fc gamma RIIA/CD32a (R167) Protein Binding Activity

accessionNumbers :

AAA35827

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human Fc gamma RIIA/CD32a protein Ala36-Ile218, with a C-terminal 10-His tag

source short :

NS0

USD :

443 USD

alt names :

CD32 antigen, CD32A, CD32MGC23887, CDw32fc-gamma-RIIa, Fc fragment of IgG, low affinity IIa, receptor (CD32), Fc fragment of IgG, low affinity IIa, receptor for (CD32), FCG2, Fc-gamma RII-a, Fc-gamma-RIIa, FcGR, FCGR2, FCGR2A, FCGR2A1, FcgRIIA, FcRII-a, FCRIIA, IGFR2MGC30032, IgG Fc receptor II-a, Immunoglobulin G Fc receptor II, low affinity immunoglobulin gamma Fc region receptor II-a

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.