Recombinant Mouse Endoglin/CD105 Fc Chimera Protein, CF | R&D Systems 1320-EN-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Endoglin/CD105 Fc Chimera Protein, CF

catalog :

1320-EN-025

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Park E, Kim S, Yao D, Savarraj J, Choi H, Chen P, et al. Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction. Int J Mol Sci. 2022;23: pubmed publisher
Rossi E, Sanz Rodriguez F, Eleno N, Düwell A, Blanco F, Langa C, et al. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood. 2013;121:403-15 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher

product information

master code :

1320-EN

SKU :

1320-EN-025

product name :

Recombinant Mouse Endoglin/CD105 Fc Chimera Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse Endoglin/CD105 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Endoglin/CD105 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Endoglin/CD105

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

86 kDa (monomer)

gene symbol :

Eng

details of functionality :

Measured by its ability to inhibit BMP-10-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 0.15-0.75 ╡g/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q8K100

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse Endoglin/CD105 protein Mouse Endoglin (Glu27-Gly581) Accession # Q8K100 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

CD105, CD105 antigen, endoglin, ENDOsler-Rendu-Weber syndrome 1, ENG, HHT1FLJ41744, ORW, ORW1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage