Recombinant Human TL1A/TNFSF15 Protein | R&D Systems 1319-TL-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TL1A/TNFSF15 Protein

catalog :

1319-TL-010

quantity :

10 ug

price :

405 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Fritsch J, Frankenheim J, Marischen L, Vadasz T, Troeger A, Rose John S, et al. Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. Cells. 2021;10: pubmed publisher
Oriol Tordera B, Olvera A, Duran Castells C, Llano A, Mothe B, Massanella M, et al. TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses. J Immunol. 2020;205:3348-3357 pubmed publisher
Landgraf K, Kloting N, Gericke M, Maixner N, Guiu Jurado E, Scholz M, et al. The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG. Cell Rep. 2020;33:108295 pubmed publisher
Sattler A, Thiel L, Ruhm A, Souidi N, Seifert M, Herberth G, et al. The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells. J Immunol. 2019;203:2970-2978 pubmed publisher
Leng T, Akther H, Hackstein C, Powell K, King T, Friedrich M, et al. TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions. Cell Rep. 2019;28:3077-3091.e5 pubmed publisher
Levin I, Zaretsky M, Aharoni A. Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion. PLoS ONE. 2017;12:e0173460 pubmed publisher
Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, et al. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 2016;6:36795 pubmed publisher
Zhou M, Liu R, Su D, Feng X, Li X. TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis. Cytokine. 2014;69:125-30 pubmed publisher
Liu C, Li X, Gao W, Liu W, Liu D. Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity. PLoS ONE. 2014;9:e92743 pubmed publisher
Reichwald K, Jørgensen T, Tougaard P, Skov S. TL1A induces TCR independent IL-6 and TNF-? production and growth of PLZF? leukocytes. PLoS ONE. 2014;9:e85793 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic N, et al. The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation. J Immunol. 2007;179:3742-51 pubmed

product information

brand :

R&D Systems

master code :

1319-TL

SKU :

1319-TL-010

product name :

Recombinant Human TL1A/TNFSF15 Protein

description :

The Recombinant Human TL1A/TNFSF15 Protein from R&D Systems is derived from E. coli. The Recombinant Human TL1A/TNFSF15 Protein has been validated for the following applications: Bioactivity.

target :

TL1A/TNFSF15

category :

Proteins and Enzymes

sizes available :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

theoretical molecular weight :

21 kDa (monomer)

gene symbol :

TNFSF15

details of functionality :

Measured by its ability to induce apoptosis of TF-1 human erythroleukemic cells. Migone, T. et al . (2002) Immunity 16 :479. The ED50 for this effect is 4-20 ng/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O95150.2

applications :

Bioactivity

source :

E. coli-derived Recombinant Human TL1A/TNFSF15 Protein

USD :

399

USD 2023 :

405 USD

alt names :

MGC129934, MGC129935, TL1A, TL1Vascular endothelial cell growth inhibitor, TNF superfamily ligand TL1A, TNFSF15, tumor necrosis factor (ligand) superfamily, member 15, tumor necrosis factor ligand superfamily member 15, vascular endothelial growth inhibitor-192A, VEGI, VEGI192A, VEGITNF ligand-related molecule 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage