product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Nodal Protein, CF
catalog :
1315-ND-025/CF
quantity :
25 ug
price :
460 USD
more info or order :
R&D Systems product webpage
citations: 12
Reference
Scerbo P, Marchal L, Kodjabachian L. Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2. elife. 2017;6: pubmed publisher
Dubrulle J, Jordan B, Akhmetova L, Farrell J, Kim S, Solnica Krezel L, et al. Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. elife. 2015;4: pubmed publisher
Jahn S, LAW M, Corsino P, Davis B, Harrison J, Law B. Signaling mechanisms that suppress the cytostatic actions of rapamycin. PLoS ONE. 2014;9:e99927 pubmed publisher
Fuller K, O Connell J, Gordon J, Mauti O, EGGENSCHWILER J. Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway. Dev Biol. 2014;391:182-95 pubmed publisher
Kumari P, Gilligan P, Lim S, Tran L, Winkler S, Philp R, et al. An essential role for maternal control of Nodal signaling. elife. 2013;2:e00683 pubmed publisher
Souquet B, Tourpin S, Messiaen S, Moison D, Habert R, Livera G. Nodal signaling regulates the entry into meiosis in fetal germ cells. Endocrinology. 2012;153:2466-73 pubmed publisher
Hansson M, Olesen D, Peterslund J, Engberg N, Kahn M, Winzi M, et al. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol. 2009;330:286-304 pubmed publisher
Borowiak M, Maehr R, Chen S, Chen A, Tang W, Fox J, et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009;4:348-58 pubmed publisher
Levine A, Levine Z, Brivanlou A. GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. Dev Biol. 2009;325:43-8 pubmed publisher
Oki S, Hashimoto R, Okui Y, Shen M, Mekada E, Otani H, et al. Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development. 2007;134:3893-904 pubmed
Lindsley R, Gill J, Kyba M, Murphy T, Murphy K. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development. 2006;133:3787-96 pubmed
Wang H, Jiang J, Zhu C, Peng C, Tsang B. Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Mol Endocrinol. 2006;20:2469-82 pubmed
product information
brand :
R&D Systems
master code :
1315-ND/CF
SKU :
1315-ND-025/CF
product name :
Recombinant Mouse Nodal Protein, CF
description :
The Recombinant Mouse Nodal Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse Nodal Protein, CF has been validated for the following applications: Bioactivity.
target :
Nodal
category :
Proteins and Enzymes
sizes available :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Mouse
theoretical molecular weight :
13 kDa (monomer)
gene symbol :
Nodal
details of functionality :
Measured by its ability to induce Smad2 phosphorylation in P19 mouse embryonal carcinoma cells. Yeo, C. et al . (2001) Mol. Cell. 7 :949. Approximately 100 ng/mL of Recombinant Mouse Nodal can effictively induce Smad2 phosphorylation.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P43021
applications :
Bioactivity
source :
E. coli-derived Recombinant Mouse Nodal Protein, CF
USD :
453
USD 2023 :
460 USD
alt names :
BMP-16, MGC138230, nodal homolog, nodal homolog (mouse), nodal, mouse, homolog
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.