This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human u-Plasminogen Activator/Urokinase, CF
catalog :
1310-SE-010
quantity :
10 ug
price :
432 USD
citations: 14
Reference
Levengood M, Carosino C, Zhang X, Lucas S, Ortiz D, Westendorf L, et al. Preclinical development of SGN-CD47M: Protease-activated antibody technology enables selective tumor targeting of the innate immune checkpoint receptor CD47. Mol Cancer Ther. 2024;: pubmed publisher
Wang Q, Shao G, Zhao X, Wong H, Chin K, Zhao M, et al. Dysregulated fibrinolysis and plasmin activation promote the pathogenesis of osteoarthritis. JCI Insight. 2024;9: pubmed publisher
Buzza M, Pawar N, Strong A, Antalis T. Intersection of Coagulation and Fibrinolysis by the Glycosylphosphatidylinositol (GPI)-Anchored Serine Protease Testisin. Int J Mol Sci. 2023;24: pubmed publisher
Howng B, Winter M, LePage C, Popova I, Krimm M, Vasiljeva O. Novel Ex Vivo Zymography Approach for Assessment of Protease Activity in Tissues with Activatable Antibodies. Pharmaceutics. 2021;13: pubmed publisher
Tan X, Banerjee P, Shi L, Xiao G, Rodriguez B, Grzeskowiak C, et al. p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi. Sci Adv. 2021;7: pubmed publisher
Kryza T, Khan T, Lovell S, Harrington B, Yin J, Porazinski S, et al. Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1. Nat Chem Biol. 2021;17:776-783 pubmed publisher
Sugioka K, Kodama Takahshi A, Sato T, Okada K, Murakami J, Park A, et al. Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2018;59:5098-5107 pubmed publisher
Pant S, Mukonoweshuro A, Desai B, Ramjee M, Selway C, Tarver G, et al. Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. J Med Chem. 2018;61:4335-4347 pubmed publisher
Han X, Bryson P, Zhao Y, Cinay G, Li S, Guo Y, et al. Masked Chimeric Antigen Receptor for Tumor-Specific Activation. Mol Ther. 2017;25:274-284 pubmed publisher
Mikuła Pietrasik J, Uruski P, Sosińska P, Maksin K, Piotrowska Kempisty H, Kucińska M, et al. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis. 2016;7:e2565 pubmed publisher
Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, et al. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 2015;212:905-25 pubmed publisher
LeBeau A, Sevillano N, Markham K, Winter M, Murphy S, Hostetter D, et al. Imaging active urokinase plasminogen activator in prostate cancer. Cancer Res. 2015;75:1225-35 pubmed publisher
Zhuo J, Tan E, Yan B, Tochhawng L, Jayapal M, Koh S, et al. Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade. PLoS ONE. 2012;7:e43594 pubmed publisher
Endo Munoz L, Cumming A, Rickwood D, Wilson D, Cueva C, Ng C, et al. Loss of osteoclasts contributes to development of osteosarcoma pulmonary metastases. Cancer Res. 2010;70:7063-72 pubmed publisher
product information
master code :
1310-SE
SKU :
1310-SE-010
product name :
Recombinant Human u-Plasminogen Activator/Urokinase, CF
unit size :
10 ug
description :
The Recombinant Human u-Plasminogen Activator/Urokinase, CF from R&D Systems is derived from NS0. The Recombinant Human u-Plasminogen Activator/Urokinase, CF has been validated for the following applications: Enzyme Activity.
target :
u-Plasminogen Activator (uPA)/Urokinase
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in HEPES, NaCl and CaCl2.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
18 kDa and 32 kDa, reducing conditions
theoretical molecular weight :
18 kDa (long A chain), 3 kDa (short A chain), 30 kDa (B chain)
gene symbol :
PLAU
details of functionality :
Measured by its ability to cleave a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is 2,000 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human u-Plasminogen Activator/Urokinase Enzyme Activity
accessionNumbers :
P00749
applications :
Enzyme Activity
source long :
Mouse myeloma cell line, NS0-derived human u-Plasminogen Activator (uPA)/Urokinase protein Met1-Leu431 with a C-terminal 10-His tag
source short :
NS0
USD :
432 USD
alt names :
ATF, EC 3.4.21, EC 3.4.21.73, plasminogen activator, urokinase, PLAU, uPA, u-PA, uPlasminogen Activator, U-plasminogen activator, urinary, Urokinase, urokinase-type plasminogen activator
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.