Recombinant Human u-Plasminogen Activator/Urokinase, CF | R&D Systems 1310-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human u-Plasminogen Activator/Urokinase, CF

catalog :

1310-SE-010

quantity :

10 ug

price :

394 USD

more info or order :

R&D Systems product webpage

citations: 11

Reference
Howng B, Winter M, LePage C, Popova I, Krimm M, Vasiljeva O. Novel Ex Vivo Zymography Approach for Assessment of Protease Activity in Tissues with Activatable Antibodies. Pharmaceutics. 2021;13: pubmed publisher
Tan X, Banerjee P, Shi L, Xiao G, Rodriguez B, Grzeskowiak C, et al. p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi. Sci Adv. 2021;7: pubmed publisher
Kryza T, Khan T, Lovell S, Harrington B, Yin J, Porazinski S, et al. Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1. Nat Chem Biol. 2021;17:776-783 pubmed publisher
Sugioka K, Kodama Takahshi A, Sato T, Okada K, Murakami J, Park A, et al. Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2018;59:5098-5107 pubmed publisher
Pant S, Mukonoweshuro A, Desai B, Ramjee M, Selway C, Tarver G, et al. Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. J Med Chem. 2018;61:4335-4347 pubmed publisher
Han X, Bryson P, Zhao Y, Cinay G, Li S, Guo Y, et al. Masked Chimeric Antigen Receptor for Tumor-Specific Activation. Mol Ther. 2017;25:274-284 pubmed publisher
MikuÅ‚a Pietrasik J, Uruski P, SosiÅ„ska P, Maksin K, Piotrowska Kempisty H, KuciÅ„ska M, et al. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis. 2016;7:e2565 pubmed publisher
Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, et al. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 2015;212:905-25 pubmed publisher
LeBeau A, Sevillano N, Markham K, Winter M, Murphy S, Hostetter D, et al. Imaging active urokinase plasminogen activator in prostate cancer. Cancer Res. 2015;75:1225-35 pubmed publisher
Zhuo J, Tan E, Yan B, Tochhawng L, Jayapal M, Koh S, et al. Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade. PLoS ONE. 2012;7:e43594 pubmed publisher
Endo Munoz L, Cumming A, Rickwood D, Wilson D, Cueva C, Ng C, et al. Loss of osteoclasts contributes to development of osteosarcoma pulmonary metastases. Cancer Res. 2010;70:7063-72 pubmed publisher

image

image 1 :

Recombinant Human u-Plasminogen Activator/Urokinase Enzyme Activity

product information

brand :

R&D Systems

master code :

1310-SE

SKU :

1310-SE-010

product name :

Recombinant Human u-Plasminogen Activator/Urokinase, CF

description :

The Recombinant Human u-Plasminogen Activator/Urokinase, CF from R&D Systems is derived from NS0. The Recombinant Human u-Plasminogen Activator/Urokinase, CF has been validated for the following applications: Enzyme Activity.

target :

u-Plasminogen Activator (uPA)/Urokinase

category :

Proteins and Enzymes

sizes available :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in HEPES, NaCl and CaCl2.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

18 kDa and 32 kDa, reducing conditions

theoretical molecular weight :

18 kDa (long A chain), 3 kDa (short A chain), 30 kDa (B chain)

gene symbol :

PLAU

details of functionality :

Measured by its ability to cleave a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is 2,000 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P00749

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human u-Plasminogen Activator/Urokinase, CF

USD :

388

USD 2023 :

394 USD

alt names :

ATF, EC 3.4.21, EC 3.4.21.73, plasminogen activator, urokinase, PLAU, uPA, u-PA, uPlasminogen Activator, U-plasminogen activator, urinary, Urokinase, urokinase-type plasminogen activator

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage