Recombinant Human/Mouse Frizzled-2 Fc Chimera Protein, CF | R&D Systems 1307-FZ-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human/Mouse Frizzled-2 Fc Chimera Protein, CF

catalog :

1307-FZ-050

quantity :

50 ug

price :

432 USD

citations: 5

Reference
Tian S, Xiong X, Zeng J, Wang S, Tremblay B, Chen P, et al. Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. Nat Commun. 2022;13:6786 pubmed publisher
Chidiac R, Abedin M, Macleod G, Yang A, Thibeault P, Blazer L, et al. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Mol Med. 2021;13:e13977 pubmed publisher
Peng Z, Simeon R, Mitchell S, Zhang J, Feng H, Chen Z. Designed Ankyrin Repeat Protein (DARPin) Neutralizers of TcdB from Clostridium difficile Ribotype 027. mSphere. 2019;4: pubmed publisher
Ramirez V, Ramos Fernández E, Henriquez J, Lorenzo A, Inestrosa N. Wnt-5a/Frizzled9 Receptor Signaling through the G?o-G?? Complex Regulates Dendritic Spine Formation. J Biol Chem. 2016;291:19092-107 pubmed publisher
Lindsley R, Gill J, Kyba M, Murphy T, Murphy K. Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development. 2006;133:3787-96 pubmed

product information

master code :

1307-FZ

SKU :

1307-FZ-050

product name :

Recombinant Human/Mouse Frizzled-2 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Human/Mouse Frizzled-2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human/Mouse Frizzled-2 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Frizzled-2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human, Mouse

observed molecular weight :

50-55 kDa, reducing conditions

theoretical molecular weight :

42.3 kDa (monomer)

gene symbol :

FZD2

details of functionality :

Measured by its ability to bind biotinylated Wnt-5a in a functional ELISA with an estimated Kd 5 nM.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9JIP6

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived Frizzled-2 protein Human/Mouse Frizzled-2 (Gln29-Leu168) Accession # Q9JIP6 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

frizzled (Drosophila) homolog 2, frizzled homolog 2 (Drosophila), frizzled-2, Frizzled2, fz-2, Fz2, FZD2, FzE2, hFz2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.