Recombinant Human MICA Fc Chimera Protein, CF | R&D Systems 1300-MA-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MICA Fc Chimera Protein, CF

catalog :

1300-MA-050

quantity :

50 ug

price :

399 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Gil Krzewska A, Saeed M, Oszmiana A, Fischer E, Lagrue K, Gahl W, et al. An actin cytoskeletal barrier inhibits lytic granule release from natural killer cells in patients with Chediak-Higashi syndrome. J Allergy Clin Immunol. 2018;142:914-927.e6 pubmed publisher
Raneros A, Puras A, Rodriguez R, Colado E, Bernal T, Anguita E, et al. Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition. Oncotarget. 2017;8:31959-31976 pubmed publisher
Lagrue K, Carisey A, Morgan D, Chopra R, Davis D. Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds. Blood. 2015;126:50-60 pubmed publisher
Brown A, Dobbie I, Alakoskela J, Davis I, Davis D. Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins. Blood. 2012;120:3729-40 pubmed publisher
Guerra S, Gonzalez J, Climent N, Reyburn H, Lopez Fernandez L, Najera J, et al. Selective induction of host genes by MVA-B, a candidate vaccine against HIV/AIDS. J Virol. 2010;84:8141-52 pubmed publisher
Nuckel H, Switala M, Sellmann L, Horn P, Durig J, Duhrsen U, et al. The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. Leukemia. 2010;24:1152-9 pubmed publisher
Kwong K, Baskar S, Zhang H, Mackall C, Rader C. Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity. J Mol Biol. 2008;384:1143-56 pubmed publisher
Diermayr S, Himmelreich H, Durovic B, Mathys Schneeberger A, Siegler U, Langenkamp U, et al. NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities. Blood. 2008;111:1428-36 pubmed
Spreu J, Stehle T, Steinle A. Human cytomegalovirus-encoded UL16 discriminates MIC molecules by their alpha2 domains. J Immunol. 2006;177:3143-9 pubmed

product information

brand :

R&D Systems

master code :

1300-MA

SKU :

1300-MA-050

product name :

Recombinant Human MICA Fc Chimera Protein, CF

unit size :

50 ug

description :

Selective inhibitor of mitotic kinesin Eg5

target :

MICA

category :

Proteins and Enzymes

alt names :

FLJ60820, MGC111087, PERB11.1

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

all available conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

90-100 kDa, reducing conditions

theoretical molecular weight :

59 kDa (monomer)

gene symbol :

MICA

details of functionality :

Measured by its ability to bind rhNKG2D/Fc Chimera in a functional ELISA.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_001170990

applications :

Binding Activity

source :

NS0-derived Recombinant Human MICA Fc Chimera Protein, CF

USD :

369

Jul-22 :

399 USD

sizes available :

50 ug

more info or order :

R&D Systems product webpage