Recombinant Human ULBP-2 Fc Chimera Protein, CF | R&D Systems 1298-UL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ULBP-2 Fc Chimera Protein, CF

catalog :

1298-UL-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Weil S, Memmer S, Lechner A, Huppert V, Giannattasio A, Becker T, et al. Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma. Front Immunol. 2017;8:387 pubmed publisher
Raneros A, Puras A, Rodriguez R, Colado E, Bernal T, Anguita E, et al. Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition. Oncotarget. 2017;8:31959-31976 pubmed publisher
Serrano Pertierra E, Cernuda Morollón E, Lopez Larrea C. Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. Eur J Immunol. 2012;42:2142-51 pubmed publisher
Nuckel H, Switala M, Sellmann L, Horn P, Durig J, Duhrsen U, et al. The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. Leukemia. 2010;24:1152-9 pubmed publisher
Ho V, Vanneman M, Kim H, Sasada T, Kang Y, Pasek M, et al. Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation. Proc Natl Acad Sci U S A. 2009;106:15825-30 pubmed publisher
Kwong K, Baskar S, Zhang H, Mackall C, Rader C. Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity. J Mol Biol. 2008;384:1143-56 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1298-UL

SKU :

1298-UL-050

product name :

Recombinant Human ULBP-2 Fc Chimera Protein, CF

Description :

The Recombinant Human ULBP-2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ULBP-2 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

ULBP-2

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

60-65 kDa, reducing conditions

theoretical molecular weight :

48 kDa (monomer)

gene symbol :

ULBP2

details of functionality :

Measured by its ability to bind Recombinant Human NKG2D/CD314 Fc Chimera (Catalog # 1299-NK ) in a functional ELISA.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9BZM5

applications :

Binding Activity

source :

NS0-derived Recombinant Human ULBP-2 Fc Chimera Protein

USD :

423 USD

alt names :

ALCAN-alpha, N2DL2, N2DL-2, NKG2D ligand 2, NKG2DL2, RAET1H, RAET1HNKG2DL2, retinoic acid early transcript 1 H, Retinoic acid early transcript 1H, UL16 binding protein 2, UL16-binding protein 2, ULBP2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage