Recombinant Human Neurturin Protein | R&D Systems 1297-NE-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Neurturin Protein

catalog :

1297-NE-025

quantity :

25 ug

price :

276 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Sun B, Yang X, Hou F, Yu X, Wang Q, Oh H, et al. Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency. Nat Microbiol. 2021;: pubmed publisher
Chu Y, Bartus R, Manfredsson F, Olanow C, Kordower J. Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease. Brain. 2020;143:960-975 pubmed publisher
Chenlo M, Rodriguez Gomez I, Serramito R, Garcia Rendueles A, Villar Taibo R, Fernandez Rodriguez E, et al. Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly. EBioMedicine. 2019;43:537-552 pubmed publisher
Ferreira J, Zheng C, Lombaert I, Goldsmith C, Cotrim A, Symonds J, et al. Neurturin Gene Therapy Protects Parasympathetic Function to Prevent Irradiation-Induced Murine Salivary Gland Hypofunction. Mol Ther Methods Clin Dev. 2018;9:172-180 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Hadaczek P, Johnston L, Forsayeth J, Bankiewicz K. Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology. 2010;58:1114-21 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher
Girard B, Young B, Buttolph T, White S, Parsons R. Regulation of neuronal pituitary adenylate cyclase-activating polypeptide expression during culture of guinea-pig cardiac ganglia. Neuroscience. 2007;146:584-93 pubmed
Girard B, Young B, Buttolph T, Locknar S, White S, Parsons R. Trophic factor modulation of cocaine- and amphetamine-regulated transcript peptide expression in explant cultured guinea-pig cardiac neurons. Neuroscience. 2006;139:1329-41 pubmed

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

1297-NE

SKU :

1297-NE-025

product name :

Recombinant Human Neurturin Protein

description :

The Recombinant Human Neurturin Protein from R&D Systems is derived from E. coli. The Recombinant Human Neurturin Protein has been validated for the following applications: Bioactivity, Binding Activity.

target :

Neurturin

unit size :

25 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

theoretical molecular weight :

11.8 kDa (monomer)

gene symbol :

NRTN

details of functionality :

Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is typically 20-80 ng/mL in the presence of Recombinant Human GFR alpha -2/GDNF R alpha -2 Fc Chimera (Catalog # 613-FR ). Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GFR alpha -2/GDNF R alpha -2 Fc Chimera (Catalog # 613-FR ) at 1 µg/mL can bind Recombinant Human Neurturin with an apparent KD 3.0 nM.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q99748

applications :

Bioactivity, Binding Activity

product keywords :

1297-NE, rhNeurturin, hNeurturin,, 1297NE, cytokinegrowthfact, cytokine, cytokines

source :

E. coli-derived Recombinant Human Neurturin Protein

USD :

273

USD 2025 :

276 USD

alt names :

neurturin, NRTN, NTN

more info or order :

R&D Systems product webpage