Recombinant Human Serpin A3 Protein, CF | R&D Systems 1295-PI-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Serpin A3 Protein, CF

catalog :

1295-PI-010

quantity :

10 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Lee H, Assaraf R, Subramanian S, Goetschius D, Bieri J, DiNunno N, et al. Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors. Nat Commun. 2024;15:9543 pubmed publisher
Silva L, Stoll T, Kryza T, Stephens C, Hastie M, Irving Rodgers H, et al. Mass spectrometry-based determination of Kallikrein-related peptidase 7 (KLK7) cleavage preferences and subsite dependency. Sci Rep. 2017;7:6789 pubmed publisher
Memari N, Jiang W, Diamandis E, Luo L. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Biol Chem. 2007;388:427-35 pubmed
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed

product information

master code :

1295-PI

SKU :

1295-PI-010

product name :

Recombinant Human Serpin A3 Protein, CF

unit size :

10 ug

description :

The Recombinant Human Serpin A3 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Serpin A3 Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Serpin A3/alpha 1-Antichymotrypsin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in HEPES and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

60-65 kDa, reducing conditions

theoretical molecular weight :

46 kDa

gene symbol :

SERPINA3

details of functionality :

Measured by its ability to inhibit chymotrypsin cleavage of a fluorogenic peptide substrate MCA-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog # ES002 ). The IC50 value is 8 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P01011

applications :

Inhibition Activity

source long :

Mouse myeloma cell line, NS0-derived human Serpin A3/alpha 1-Antichymotrypsin protein Asn26-Ala423, with a C-terminal 10-His tag

source short :

NS0

USD :

432 USD

alt names :

AACTMGC88254, ACTGIG25, alpha 1-Antichymotrypsin, alpha-1-antichymotrypsin, antitrypsin), member 3, Cell growth-inhibiting gene 24/25 protein, growth-inhibiting protein 24, growth-inhibiting protein 25, member 3, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, serine (or cysteine) proteinase inhibitor, clade A, member 3, Serpin A3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage