Recombinant Human TREM-1 Fc Chimera Protein, CF | R&D Systems 1278-TR-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TREM-1 Fc Chimera Protein, CF

catalog :

1278-TR-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Sudom A, Talreja S, Danao J, Bragg E, Kegel R, Min X, et al. Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J Biol Chem. 2018;293:12634-12646 pubmed publisher
Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
Horonenko G, Hoyt J, Robbins R, Singarajah C, Umar A, Pattengill J, et al. Soluble triggering receptor expressed on myeloid cell-1 is increased in patients with ventilator-associated pneumonia: a preliminary report. Chest. 2007;132:58-63 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1278-TR

SKU :

1278-TR-050

product name :

Recombinant Human TREM-1 Fc Chimera Protein, CF

Description :

The Recombinant Human TREM-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TREM-1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

TREM-1

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

60-70 kDa, reducing conditions

theoretical molecular weight :

47 kDa (monomer)

gene symbol :

TREM1

details of functionality :

Measured by its ability to block anti-TREM-1-induced TNF-alpha secretion by human peripheral blood mononuclear cells (PBMC). At 1 µg/mL, Recombinant Human TREM-1 Fc Chimera is able to block 70% of Goat Anti-Human TREM-1 (20 µg/mL, 200 µL/well) (Catalog # AF1278) induced TNF-alpha released from 1 x 105 cells.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9NP99

applications :

Bioactivity

source :

NS0-derived Recombinant Human TREM-1 Fc Chimera Protein

USD :

423 USD

alt names :

CD354, CD354 antigen, TREM1, TREM-1Triggering receptor expressed on monocytes 1, triggering receptor expressed on myeloid cells 1, triggering-receptor TREM1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage