This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Jagged 1 Fc Chimera Protein, CF
catalog :
1277-JG
quantity :
50 ug
price :
339 USD
citations: 28
Reference
Batista M, Diniz P, Torres A, Murta D, Lopes da Costa L, Silva E. Notch signaling in mouse blastocyst development and hatching. BMC Dev Biol. 2020;20:9 pubmed publisher
Lopez Guerra M, Xargay Torrent S, Fuentes P, Roldán J, González Farre B, Rosich L, et al. Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells. Oncogene. 2020;39:1185-1197 pubmed publisher
Chung S, Shen W, Davidson K, Pebay A, Wong R, Yau B, et al. Differentiation of Retinal Glial Cells From Human Embryonic Stem Cells by Promoting the Notch Signaling Pathway. Front Cell Neurosci. 2019;13:527 pubmed publisher
Matsui S, Ochiai M, Yasuda K, Mae S, Kotaka M, Toyoda T, et al. Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line. Stem Cell Res. 2019;35:101400 pubmed publisher
Stephenson S, Care M, Fan I, Zougman A, Westhead D, Doody G, et al. Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. J Immunol. 2019;202:1287-1300 pubmed publisher
Schwentner R, Jug G, Kauer M, Schnöller T, Waidhofer Söllner P, Holter W, et al. JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans cell histiocytosis-like cells. J Leukoc Biol. 2019;105:101-111 pubmed publisher
Lee S, Long F. Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation. J Clin Invest. 2018;128:5573-5586 pubmed publisher
Manokawinchoke J, Nattasit P, Thongngam T, Pavasant P, Tompkins K, Egusa H, et al. RNA sequencing data of Notch ligand treated human dental pulp cells. Data Brief. 2018;17:407-413 pubmed publisher
Antila C, Rraklli V, Blomster H, Dahlström K, Salminen T, Holmberg J, et al. Sumoylation of Notch1 represses its target gene expression during cell stress. Cell Death Differ. 2018;25:600-615 pubmed publisher
Youngstrom D, Senos R, Zondervan R, Brodeur J, Lints A, Young D, et al. Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects. NPJ Regen Med. 2017;2:32 pubmed publisher
Gocha T, Rao B, DasGupta R. Identification and characterization of a novel Sso7d scaffold-based binder against Notch1. Sci Rep. 2017;7:12021 pubmed publisher
Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, et al. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep. 2017;7:5590 pubmed publisher
Liu Z, Li C, Meng X, Bai Y, Qi J, Wang J, et al. Hypoxia-inducible factor-l? mediates aggrecan and collagen ? expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration. Biochem Biophys Res Commun. 2017;488:554-561 pubmed publisher
Ciria M, García N, Ontoria Oviedo I, González King H, Carrero R, de la Pompa J, et al. Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1α Upstream of Notch and SUMO Pathways. Stem Cells Dev. 2017;26:973-985 pubmed publisher
Kibbie J, Teles R, Wang Z, Hong P, Montoya D, Krutzik S, et al. Jagged1 Instructs Macrophage Differentiation in Leprosy. PLoS Pathog. 2016;12:e1005808 pubmed publisher
Rouch J, Scott A, Lei N, Solorzano Vargas R, Wang J, Hanson E, et al. Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids. PLoS ONE. 2016;11:e0148216 pubmed publisher
Procopio M, László C, Al Labban D, Kim D, Bordignon P, Jo S, et al. Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation. Nat Cell Biol. 2015;17:1193-204 pubmed publisher
Shao S, Zhao X, Zhang X, Luo M, Zuo X, Huang S, et al. Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner. Mol Cancer. 2015;14:28 pubmed publisher
Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu Kaoud N, Halabi N, et al. Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. J Transl Med. 2015;13:27 pubmed publisher
Hirata N, Yamada S, Shoda T, Kurihara M, Sekino Y, Kanda Y. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat Commun. 2014;5:4806 pubmed publisher
Ranga A, Gobaa S, Okawa Y, Mosiewicz K, Negro A, Lutolf M. 3D niche microarrays for systems-level analyses of cell fate. Nat Commun. 2014;5:4324 pubmed publisher
Guichet P, Guelfi S, Teigell M, Hoppe L, Bakalara N, Bauchet L, et al. Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells. Stem Cells. 2015;33:21-34 pubmed publisher
Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton D, et al. Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-?B interaction. PLoS ONE. 2014;9:e95400 pubmed publisher
Osathanon T, Manokawinchoke J, Nowwarote N, Aguilar P, Palaga T, Pavasant P. Notch signaling is involved in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells. Stem Cells Dev. 2013;22:1220-31 pubmed publisher
Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Küchler A, WEISS M, et al. The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol. 2012;181:1099-111 pubmed publisher
Lavoz C, Rodrígues Díez R, Benito Martin A, Rayego Mateos S, Rodrigues Díez R, Alique M, et al. Angiotensin II contributes to renal fibrosis independently of Notch pathway activation. PLoS ONE. 2012;7:e40490 pubmed publisher
Emdad L, D Souza S, Kothari H, Qadeer Z, Germano I. Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes. Stem Cells Dev. 2012;21:404-10 pubmed publisher
Piggott K, Deng J, Warrington K, Younge B, Kubo J, Desai M, et al. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Circulation. 2011;123:309-18 pubmed publisher
product information
brand :
R&D Systems
master code :
1277-JG
SKU :
1277-JG-050
product name :
Recombinant Human Jagged 1 Fc Chimera Protein, CF
description :
The Recombinant Human Jagged 1 Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Jagged 1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Jagged 1
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS and EDTA.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
170-180 kDa, under reducing conditions
theoretical molecular weight :
137 kDa
gene symbol :
JAG1
details of functionality :
Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 0.5-2.0 µg/mL.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
1277-JG
accessionNumbers :
P78504
applications :
Bioactivity
source :
Chinese Hamster Ovary cell line, CHO-derived human Jagged 1 protein Human Jagged 1 (Ser32-Ser1046) Accession # P78504 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
2020 USD :
339
2021 USD :
339 USD
alt names :
AGS, AHDMGC104644, Alagille syndrome, AWS, CD339, CD339 antigen, HJ1, JAG1, jagged 1, Jagged1, JAGL1, protein jagged-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.