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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Jagged 1 Fc Chimera Protein, CF
catalog :
1277-JG-050
quantity :
50 ug
price :
432 USD
more info or order :
citations: 48
Reference
Cho S, Servi xe1 n Morilla E, Garrido V, Rodriguez Gonzalez B, Yuan Y, Cano R, et al. The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice. bioRxiv. 2024;: pubmed publisher
Carolina E, Kuse Y, Okumura A, Aoshima K, Tadokoro T, Matsumoto S, et al. Generation of human iPSC-derived 3D bile duct within liver organoid by incorporating human iPSC-derived blood vessel. Nat Commun. 2024;15:7424 pubmed publisher
Herrera J, Komatsu M. Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1. Cell Rep. 2024;43:113837 pubmed publisher
Jovanovic V, Weber C, Slamecka J, Ryu S, Chu P, Sen C, et al. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells. Stem Cell Reports. 2023;18:1701-1720 pubmed publisher
Dave B, Chen X, McCready F, Charton C, Morley R, Tailor J, et al. Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. Development. 2023;150: pubmed publisher
Li D, Sun A, Zhang L, Ding Z, Yi F, Yang X, et al. Elevated ITGA5 facilitates hyperactivated mTORC1-mediated progression of laryngeal squamous cell carcinoma via upregulation of EFNB2. Theranostics. 2022;12:7431-7449 pubmed publisher
Chansaenroj A, Kornsuthisopon C, Roytrakul S, Phothichailert S, Rochanavibhata S, Fournier B, et al. Indirect Immobilised Jagged-1 Enhances Matrisome Proteins Associated with Osteogenic Differentiation of Human Dental Pulp Stem Cells: A Proteomic Study. Int J Mol Sci. 2022;23: pubmed publisher
Filipovi x107 M, Flegar D, x160 u x107 ur A, x160 isl D, Kavazovi x107 I, Antica M, et al. Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions. Front Immunol. 2022;13:902947 pubmed publisher
Kornsuthisopon C, Chansaenroj A, Manokawinchoke J, Tompkins K, Pirarat N, Osathanon T. Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells. Sci Rep. 2022;12:7583 pubmed publisher
Roos F, van Tienderen G, Wu H, Bordeu I, Vinke D, Albarinos L, et al. Human branching cholangiocyte organoids recapitulate functional bile duct formation. Cell Stem Cell. 2022;29:776-794.e13 pubmed publisher
Zohorsky K, Lin S, Mequanint K. Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway. Cells. 2021;10: pubmed publisher
Wang Y, Chang J, Wang Z, Li Y. Sirt3 promotes the autophagy of HK‑2 human proximal tubular epithelial cells via the inhibition of Notch‑1/Hes‑1 signaling. Mol Med Rep. 2021;24: pubmed publisher
Zhao Z, Shen X, Zhang D, Xiao H, Kong H, Yang B, et al. miR-153 enhances the therapeutic effect of radiotherapy by targeting JAG1 in pancreatic cancer cells. Oncol Lett. 2021;21:300 pubmed publisher
Shimizu S, Yoshioka K, Aki S, Takuwa Y. Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells. Sci Rep. 2021;11:5199 pubmed publisher
Uchimura K, Wu H, Yoshimura Y, Humphreys B. Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling. Cell Rep. 2020;33:108514 pubmed publisher
Kakuda S, LoPilato R, Ito A, Haltiwanger R. Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2. J Biol Chem. 2020;295:14710-14722 pubmed publisher
Manokawinchoke J, Sumrejkanchanakij P, Boonprakong L, Pavasant P, Egusa H, Osathanon T. NOTCH2 participates in Jagged1-induced osteogenic differentiation in human periodontal ligament cells. Sci Rep. 2020;10:13329 pubmed publisher
Fan J, Shen W, Lee S, Mathai A, Zhang R, Xu G, et al. Targeting the Notch and TGF-β signaling pathways to prevent retinal fibrosis in vitro and in vivo. Theranostics. 2020;10:7956-7973 pubmed publisher
Wei K, Korsunsky I, Marshall J, Gao A, Watts G, Major T, et al. Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature. 2020;582:259-264 pubmed publisher
Batista M, Diniz P, Torres A, Murta D, Lopes da Costa L, Silva E. Notch signaling in mouse blastocyst development and hatching. BMC Dev Biol. 2020;20:9 pubmed publisher
Chung S, Shen W, Davidson K, Pebay A, Wong R, Yau B, et al. Differentiation of Retinal Glial Cells From Human Embryonic Stem Cells by Promoting the Notch Signaling Pathway. Front Cell Neurosci. 2019;13:527 pubmed publisher
Lopez Guerra M, Xargay Torrent S, Fuentes P, Roldán J, González Farre B, Rosich L, et al. Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells. Oncogene. 2020;39:1185-1197 pubmed publisher
Kannan S, Aitken M, Herbrich S, Golfman L, Hall M, Mak D, et al. Anti-Leukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia. Mol Cancer Ther. 2019;: pubmed publisher
Matsui S, Ochiai M, Yasuda K, Mae S, Kotaka M, Toyoda T, et al. Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line. Stem Cell Res. 2019;35:101400 pubmed publisher
Stephenson S, Care M, Fan I, Zougman A, Westhead D, Doody G, et al. Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. J Immunol. 2019;202:1287-1300 pubmed publisher
Schwentner R, Jug G, Kauer M, Schnöller T, Waidhofer Söllner P, Holter W, et al. JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans cell histiocytosis-like cells. J Leukoc Biol. 2019;105:101-111 pubmed publisher
Lee S, Long F. Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation. J Clin Invest. 2018;128:5573-5586 pubmed publisher
Manokawinchoke J, Nattasit P, Thongngam T, Pavasant P, Tompkins K, Egusa H, et al. RNA sequencing data of Notch ligand treated human dental pulp cells. Data Brief. 2018;17:407-413 pubmed publisher
Antila C, Rraklli V, Blomster H, Dahlström K, Salminen T, Holmberg J, et al. Sumoylation of Notch1 represses its target gene expression during cell stress. Cell Death Differ. 2018;25:600-615 pubmed publisher
Youngstrom D, Senos R, Zondervan R, Brodeur J, Lints A, Young D, et al. Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects. NPJ Regen Med. 2017;2:32 pubmed publisher
Gocha T, Rao B, DasGupta R. Identification and characterization of a novel Sso7d scaffold-based binder against Notch1. Sci Rep. 2017;7:12021 pubmed publisher
Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, et al. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep. 2017;7:5590 pubmed publisher
Liu Z, Li C, Meng X, Bai Y, Qi J, Wang J, et al. Hypoxia-inducible factor-l? mediates aggrecan and collagen ? expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration. Biochem Biophys Res Commun. 2017;488:554-561 pubmed publisher
Ciria M, García N, Ontoria Oviedo I, González King H, Carrero R, de la Pompa J, et al. Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1α Upstream of Notch and SUMO Pathways. Stem Cells Dev. 2017;26:973-985 pubmed publisher
Kibbie J, Teles R, Wang Z, Hong P, Montoya D, Krutzik S, et al. Jagged1 Instructs Macrophage Differentiation in Leprosy. PLoS Pathog. 2016;12:e1005808 pubmed publisher
Rouch J, Scott A, Lei N, Solorzano Vargas R, Wang J, Hanson E, et al. Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids. PLoS ONE. 2016;11:e0148216 pubmed publisher
Procopio M, László C, Al Labban D, Kim D, Bordignon P, Jo S, et al. Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation. Nat Cell Biol. 2015;17:1193-204 pubmed publisher
Shao S, Zhao X, Zhang X, Luo M, Zuo X, Huang S, et al. Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner. Mol Cancer. 2015;14:28 pubmed publisher
Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu Kaoud N, Halabi N, et al. Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. J Transl Med. 2015;13:27 pubmed publisher
Hirata N, Yamada S, Shoda T, Kurihara M, Sekino Y, Kanda Y. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat Commun. 2014;5:4806 pubmed publisher
Ranga A, Gobaa S, Okawa Y, Mosiewicz K, Negro A, Lutolf M. 3D niche microarrays for systems-level analyses of cell fate. Nat Commun. 2014;5:4324 pubmed publisher
Guichet P, Guelfi S, Teigell M, Hoppe L, Bakalara N, Bauchet L, et al. Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells. Stem Cells. 2015;33:21-34 pubmed publisher
Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton D, et al. Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-?B interaction. PLoS ONE. 2014;9:e95400 pubmed publisher
Osathanon T, Manokawinchoke J, Nowwarote N, Aguilar P, Palaga T, Pavasant P. Notch signaling is involved in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells. Stem Cells Dev. 2013;22:1220-31 pubmed publisher
Sundlisaeter E, Edelmann R, Hol J, Sponheim J, Küchler A, WEISS M, et al. The alarmin IL-33 is a notch target in quiescent endothelial cells. Am J Pathol. 2012;181:1099-111 pubmed publisher
Lavoz C, Rodrígues Díez R, Benito Martin A, Rayego Mateos S, Rodrigues Díez R, Alique M, et al. Angiotensin II contributes to renal fibrosis independently of Notch pathway activation. PLoS ONE. 2012;7:e40490 pubmed publisher
Emdad L, D Souza S, Kothari H, Qadeer Z, Germano I. Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes. Stem Cells Dev. 2012;21:404-10 pubmed publisher
Piggott K, Deng J, Warrington K, Younge B, Kubo J, Desai M, et al. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Circulation. 2011;123:309-18 pubmed publisher
product information
master code :
1277-JG
SKU :
1277-JG-050
product name :
Recombinant Human Jagged 1 Fc Chimera Protein, CF
unit size :
50 ug
description :
The Recombinant Human Jagged 1 Fc Chimera Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Jagged 1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Jagged 1
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS and EDTA.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
170-180 kDa, under reducing conditions
theoretical molecular weight :
137 kDa
gene symbol :
JAG1
details of functionality :
Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. Nobta, M. et al . (2005) J. Biol. Chem. 280 :15842. The ED50 for this effect is 0.5-2.0 ╡g/mL.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P78504
applications :
Bioactivity
source long :
Chinese Hamster Ovary cell line, CHO-derived human Jagged 1 protein Human Jagged 1 (Ser32-Ser1046) Accession # P78504 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
source short :
CHO
USD :
432 USD
alt names :
AGS, AHDMGC104644, Alagille syndrome, AWS, CD339, CD339 antigen, HJ1, JAG1, jagged 1, Jagged1, JAGL1, protein jagged-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.