Recombinant Human IL-36Ra/IL-1F5 Protein, CF | R&D Systems 1275-IL-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-36Ra/IL-1F5 Protein, CF

catalog :

1275-IL-025/CF

quantity :

25 ug

price :

396 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Le N, Luk I, Chisanga D, Shi W, Pang L, Scholz G, et al. IL-36G promotes cancer-cell intrinsic hallmarks in human gastric cancer cells. Cytokine. 2022;155:155887 pubmed publisher
Mercurio L, Failla C, Capriotti L, Scarponi C, Facchiano F, Morelli M, et al. Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responses. PLoS ONE. 2020;15:e0222969 pubmed publisher
Mercurio L, Morelli M, Scarponi C, Eisenmesser E, Doti N, Pagnanelli G, et al. IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment. Cell Death Dis. 2018;9:1104 pubmed publisher
Zhang J, Yin Y, Lin X, Yan X, Xia Y, Zhang L, et al. IL-36 induces cytokine IL-6 and chemokine CXCL8 expression in human lung tissue cells: Implications for pulmonary inflammatory responses. Cytokine. 2017;99:114-123 pubmed publisher
Schmitt V, Hahn M, KÃ¤stele V, Wagner O, Wiendl M, Derer A, et al. Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts. Eur J Immunol. 2017;47:2101-2112 pubmed publisher
Yi G, Ybe J, Saha S, Caviness G, Raymond E, Ganesan R, et al. Structural and Functional Attributes of the Interleukin-36 Receptor. J Biol Chem. 2016;291:16597-609 pubmed publisher
Saha S, Singh D, Raymond E, Ganesan R, Caviness G, Grimaldi C, et al. Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor. J Biol Chem. 2015;290:23997-4006 pubmed publisher
van de Veerdonk F, Stoeckman A, Wu G, Boeckermann A, Azam T, Netea M, et al. IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc Natl Acad Sci U S A. 2012;109:3001-5 pubmed publisher

image

image 1 :

Recombinant Human IL-36Ra/IL-1F5 Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1275-IL/CF

SKU :

1275-IL-025/CF

product name :

Recombinant Human IL-36Ra/IL-1F5 Protein, CF

Description :

The Recombinant Human IL-36Ra/IL-1F5 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human IL-36Ra/IL-1F5 Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-36Ra/IL-1F5

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

theoretical molecular weight :

17 kDa

gene symbol :

IL36RN

details of functionality :

Measured by its ability to inhibit IL-36 alpha , IL-36 beta or IL-36 gamma-induced IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is 0.2-1 µg/mL in the presence of 10 ng/mL of recombinant human IL-36 beta .

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9UBH0

applications :

Bioactivity

source :

E. coli-derived Recombinant Human IL-36Ra/IL-1F5 Protein

USD :

396 USD

alt names :

FIL1, FIL1 delta, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta), FIL1DIL-1 delta, IL1F5, IL1F5 (Canonical product IL-1F5a), IL-1HY1, IL-1L1, IL-1RP3, IL36RA, IL-36RA, IL36RN, interleukin 1 family, member 5 (delta), interleukin 1, delta, Interleukin 36 Receptor Antagonist, interleukin-1 family member 5, Interleukin-1 HY1, Interleukin-1 receptor antagonist homolog 1, Interleukin-1-like protein 1, Interleukin-36 Receptor Antagonist

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage