Recombinant Human Serpin C1/Antithrombin-III Protein, CF | R&D Systems 1267-PI product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Serpin C1/Antithrombin-III Protein, CF

catalog :

1267-PI

quantity :

10 ug

price :

339 USD

citations: 4

Reference
Wang J, Zhang Y, Sze S, Van de Weg S, Vernooij F, Schoneveld A, et al. Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles. Int J Mol Sci. 2017;19: pubmed publisher
Ayala Lujan J, Vijayakumar V, Gong M, Smith R, Santiago A, Ruiz Perez F. Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytes. PLoS ONE. 2014;9:e107920 pubmed publisher
Memari N, Jiang W, Diamandis E, Luo L. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Biol Chem. 2007;388:427-35 pubmed
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed

product information

brand :

R&D Systems

master code :

1267-PI

SKU :

1267-PI-010

product name :

Recombinant Human Serpin C1/Antithrombin-III Protein, CF

description :

The Recombinant Human Serpin C1/Antithrombin-III Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Serpin C1/Antithrombin-III Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Serpin C1/Antithrombin-III

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

55-65 kDa, reducing conditions

theoretical molecular weight :

50 kDa

gene symbol :

SERPINC1

details of functionality :

Measured by its ability to inhibit Recombinant Human Coagulation Factor II/Thrombin (Catalog # 1473-SE ) cleavage of a fluorogenic peptide substrate Boc-VPR-AMC (Catalog # ES011 ). The IC50 value is 5 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1267-PI

accessionNumbers :

P01008

applications :

Inhibition Activity

source :

Mouse myeloma cell line, NS0-derived human Serpin C1/Antithrombin-III protein His33-Lys464, with a C-terminal 10-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

Antithrombin-III, AT3antithrombin-III, ATIII, ATIIIantithrombin III, MGC22579, serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, serine-cysteine proteinase inhibitor clade C member 1, Serpin C1, serpin peptidase inhibitor, clade C (antithrombin), member 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.