Recombinant Human Serpin C1/Antithrombin-III Protein, CF | R&D Systems 1267-PI-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Serpin C1/Antithrombin-III Protein, CF

catalog :

1267-PI-010

quantity :

10 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Lim X, Huang C, Yatim S, Chong S, Tan S, Yang X, et al. Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction. Int J Mol Sci. 2022;24: pubmed publisher
Biswas S, Chen E, Gao Y, Lee S, Hewlett I, Devadas K. Modulation of HIV Replication in Monocyte-Derived Macrophages (MDM) by Host Antiviral Factors Secretory Leukocyte Protease Inhibitor and Serpin Family C Member 1 Induced by Steroid Hormones. Viruses. 2022;14: pubmed publisher
Wang J, Zhang Y, Sze S, Van de Weg S, Vernooij F, Schoneveld A, et al. Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles. Int J Mol Sci. 2017;19: pubmed publisher
Ayala Lujan J, Vijayakumar V, Gong M, Smith R, Santiago A, Ruiz Perez F. Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytes. PLoS ONE. 2014;9:e107920 pubmed publisher
Memari N, Jiang W, Diamandis E, Luo L. Enzymatic properties of human kallikrein-related peptidase 12 (KLK12). Biol Chem. 2007;388:427-35 pubmed
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1267-PI

SKU :

1267-PI-010

product name :

Recombinant Human Serpin C1/Antithrombin-III Protein, CF

Description :

The Recombinant Human Serpin C1/Antithrombin-III Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Serpin C1/Antithrombin-III Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Serpin C1/Antithrombin-III

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MES and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

55-65 kDa, reducing conditions

theoretical molecular weight :

50 kDa

gene symbol :

SERPINC1

details of functionality :

Measured by its ability to inhibit Recombinant Human Coagulation Factor II/Thrombin (Catalog # 1473-SE ) cleavage of a fluorogenic peptide substrate Boc-VPR-AMC (Catalog # ES011 ). The IC50 value is 5 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P01008

applications :

Inhibition Activity

source :

NS0-derived Recombinant Human Serpin C1/Antithrombin-III Protein

USD :

423 USD

alt names :

Antithrombin-III, AT3antithrombin-III, ATIII, ATIIIantithrombin III, MGC22579, serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, serine-cysteine proteinase inhibitor clade C member 1, Serpin C1, serpin peptidase inhibitor, clade C (antithrombin), member 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage