Recombinant Human Fas Ligand/TNFSF6 Protein, CF | R&D Systems 126-FL-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Fas Ligand/TNFSF6 Protein, CF

catalog :

126-FL-010/CF

quantity :

10 ug

price :

399 USD

more info or order :

R&D Systems product webpage

citations: 18

Reference
Velard F, Chatron Colliet A, Côme D, Ah Kioon M, Lin H, Hafsia N, et al. Adrenomedullin and truncated peptide adrenomedullin(22-52) affect chondrocyte response to apoptotis in vitro: downregulation of FAS protects chondrocyte from cell death. Sci Rep. 2020;10:16740 pubmed publisher
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed publisher
Frank Bertoncelj M, Pisetsky D, Kolling C, Michel B, Gay R, Jungel A, et al. TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles. Front Immunol. 2018;9:28 pubmed publisher
Han N, Shi L, Guo Q, Sun W, Yu Y, Yang L, et al. HAT1 induces lung cancer cell apoptosis via up regulating Fas. Oncotarget. 2017;8:89970-89977 pubmed publisher
You B, Han B, Park W. Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells. Oncotarget. 2017;8:17726-17737 pubmed publisher
Chang L, Li Y, Kaplan D. Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis. Sci Rep. 2016;6:36862 pubmed publisher
Cui X, Zhang L, Magli A, Catera R, Yan X, Griffin D, et al. Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability. Leukemia. 2016;30:74-85 pubmed publisher
Liang D, Hou Y, Lou X, Chen H. Decoy Receptor 3 Improves Survival in Experimental Sepsis by Suppressing the Inflammatory Response and Lymphocyte Apoptosis. PLoS ONE. 2015;10:e0131680 pubmed publisher
Li B, Baylink D, Walter M, Lau K, Meng X, Wang J, et al. Targeted 25-hydroxyvitamin D3 1Î±-hydroxylase adoptive gene therapy ameliorates dss-induced colitis without causing hypercalcemia in mice. Mol Ther. 2015;23:339-51 pubmed publisher
You B, Park W. Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels. Int J Oncol. 2014;44:1745-55 pubmed publisher
Takahashi Y, Byrareddy S, Albrecht C, Brameier M, Walter L, Mayne A, et al. In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection. PLoS Pathog. 2014;10:e1003929 pubmed publisher
Kyathanahalli C, Marks J, Nye K, Lao B, Albrecht E, Aberdeen G, et al. Cross-species withdrawal of MCL1 facilitates postpartum uterine involution in both the mouse and baboon. Endocrinology. 2013;154:4873-84 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Sagiv A, Biran A, Yon M, Simon J, Lowe S, Krizhanovsky V. Granule exocytosis mediates immune surveillance of senescent cells. Oncogene. 2013;32:1971-7 pubmed publisher
Stephenson Famy A, Marks J, Suresh A, Caritis S, Simhan H, Jeyasuria P, et al. Antiapoptotic signaling via MCL1 confers resistance to caspase-3-mediated apoptotic cell death in the pregnant human uterine myocyte. Mol Endocrinol. 2012;26:320-30 pubmed publisher
Lobito A, Ramani S, Tom I, Bazan J, Luis E, Fairbrother W, et al. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. J Biol Chem. 2011;286:18969-81 pubmed publisher
Titanji K, Velu V, Chennareddi L, Vijay Kumar M, Gewirtz A, Freeman G, et al. Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. J Clin Invest. 2010;120:3878-90 pubmed publisher
De Milito A, Iessi E, Logozzi M, Lozupone F, Spada M, Marino M, et al. Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species. Cancer Res. 2007;67:5408-17 pubmed

product information

brand :

R&D Systems

master code :

126-FL/CF

SKU :

126-FL-010/CF

product name :

Recombinant Human Fas Ligand/TNFSF6 Protein, CF

unit size :

10 ug

description :

nAChR agonist; displays selectivity for 4 2, 1 and 3 4 subtypes

target :

Fas Ligand/TNFSF6

category :

Proteins and Enzymes

alt names :

apoptosis (APO-1) antigen ligand 1, Apoptosis antigen ligand, APT1LG1CD95L, APTL, CD178, CD178 antigen, CD95L, CD95-L, Fas antigen ligand, Fas ligand, Fas ligand (TNF superfamily, member 6), FASLCD95 ligand, FASLG, TNFSF6, TNFSF6FasL, tumor necrosis factor (ligand) superfamily, member 6, tumor necrosis factor ligand superfamily member 6

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

all available conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

19 - 32 kDa, reducing conditions

theoretical molecular weight :

18 kDa

gene symbol :

FASLG

details of functionality :

Measured by its ability to induce apoptosis of Jurkat human acute T cell leukemia cells. The ED50 for this effect is 0.3-1.5 ng/mL in the presence of 10 µg/mL of a cross-linking antibody Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050 ).

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q53ZZ1

applications :

Bioactivity

source :

CHO-derived Recombinant Human Fas Ligand/TNFSF6 Protein, CF

USD :

369

Jul-22 :

399 USD

sizes available :

10 ug

more info or order :

R&D Systems product webpage