product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-17E Protein
catalog :
1258-IL-025
quantity :
25 ug
price :
400 USD
more info or order :
R&D Systems product webpage
citations: 20
Reference
Xiao G, Kumar R, Komuro Y, Burguet J, Kakarla V, Azizkhanian I, et al. IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury. Cell Rep. 2022;41:111848 pubmed publisher
Petrova T, Pesic J, Pardali K, Gaestel M, Arthur J. p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells. Sci Rep. 2020;10:3479 pubmed publisher
Hochdörfer T, Winkler C, Pardali K, Mjösberg J. Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells. Eur J Immunol. 2019;49:884-893 pubmed publisher
Qin X, Liu M, Zhang S, Wang C, Zhang T. The role of IL-36γ and its regulation in eosinophilic inflammation in allergic rhinitis. Cytokine. 2019;117:84-90 pubmed publisher
Tang W, Smith S, Du W, Gugilla A, Du J, Oliveria J, et al. Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma. Clin Transl Allergy. 2018;8:5 pubmed publisher
Lombardi V, Luce S, Moussu H, Morizur L, Gueguen C, Neukirch C, et al. Effector and regulatory dendritic cells display distinct patterns of miRNA expression. Immun Inflamm Dis. 2017;5:310-317 pubmed publisher
Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, et al. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med. 2015;212:619-31 pubmed publisher
Yao X, Wang W, Li Y, Huang P, Zhang Q, Wang J, et al. IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model. Respir Res. 2015;16:39 pubmed publisher
Wu L, Wang C, Boisson B, Misra S, Rayman P, Finke J, et al. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling. J Immunol. 2014;193:1590-9 pubmed publisher
Teunissen M, Munneke J, Bernink J, Spuls P, Res P, te Velde A, et al. Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol. 2014;134:2351-2360 pubmed publisher
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, et al. Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol. 2014;44:370-85 pubmed publisher
Boisson B, Wang C, Pedergnana V, Wu L, Cypowyj S, Rybojad M, et al. An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity. 2013;39:676-86 pubmed publisher
Hvid M, Vestergaard C, Kemp K, Christensen G, Deleuran B, Deleuran M. IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction?. J Invest Dermatol. 2011;131:150-7 pubmed publisher
Terrier B, Bieche I, Maisonobe T, Laurendeau I, Rosenzwajg M, Kahn J, et al. Interleukin-25: a cytokine linking eosinophils and adaptive immunity in Churg-Strauss syndrome. Blood. 2010;116:4523-31 pubmed publisher
Xu G, Zhang L, Wang D, Xu R, Liu Z, Han D, et al. Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. Allergy. 2010;65:581-9 pubmed publisher
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, et al. Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer. 2009;125:367-73 pubmed publisher
Rickel E, Siegel L, Yoon B, Rottman J, Kugler D, Swart D, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 2008;181:4299-310 pubmed
Cherry W, Yoon J, Bartemes K, Iijima K, Kita H. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol. 2008;121:1484-90 pubmed publisher
Letuve S, Lajoie Kadoch S, Audusseau S, Rothenberg M, Fiset P, Ludwig M, et al. IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. J Allergy Clin Immunol. 2006;117:590-6 pubmed
Wong C, Cheung P, Ip W, Lam C. Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB. Am J Respir Cell Mol Biol. 2005;33:186-94 pubmed
image
image 1 :
R&D Systems 1258-IL-025 image 1
Recombinant Human IL-17E Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
1258-IL
SKU :
1258-IL-025
product name :
Recombinant Human IL-17E Protein
description :
The Recombinant Human IL-17E Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-17E Protein has been validated for the following applications: Bioactivity.
target :
IL-17E/IL-25
unit size :
25 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
theoretical molecular weight :
17 kDa (monomer)
gene symbol :
IL25
details of functionality :
Measured by its ability to induce CXCL1/GRO alpha secretion in HT-29 human colon adenocarcinoma cells. The ED50 for this effect is 0.25-1.5 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9H293
applications :
Bioactivity
product keywords :
1258-IL, rhIL-17E, hIL-17E,, 1258IL, cytokinegrowthfact, IL17E, IL 17E, IL-17 E, Interleukin 17E, Interleukin-17E, Interleukin-17 E, cytokine, cytokines
source :
E. coli-derived Recombinant Human IL-17E Protein
USD :
396
USD 2025 :
400 USD
alt names :
IL17E, IL-17E, IL25, IL-25, interleukin 25, Interleukin-17E, interleukin-25
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.