Recombinant Human Fc gamma RI/CD64 Protein, CF | R&D Systems 1257-FC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Fc gamma RI/CD64 Protein, CF

catalog :

1257-FC

quantity :

50 ug

price :

349 USD

citations: 14

Reference
Blundell P, Lu D, Wilkinson M, Dell A, Haslam S, Pleass R. Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus. J Immunol. 2019;202:1595-1611 pubmed publisher
Oshima T, Miyashita H, Ishimura Y, Ito Y, Tanaka Y, Hori A, et al. Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey. PLoS ONE. 2018;13:e0196422 pubmed publisher
Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
Geuijen K, Oppers Tiemissen C, Egging D, Simons P, Boon L, Schasfoort R, et al. Rapid screening of IgG quality attributes - effects on Fc receptor binding. FEBS Open Bio. 2017;7:1557-1574 pubmed publisher
Järnum S, Runström A, Bockermann R, Winstedt L, Crispin M, Kjellman C. Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy. Mol Cancer Ther. 2017;16:1887-1897 pubmed publisher
Wessels U, Schick E, Ritter M, Kowalewsky F, Heinrich J, Stubenrauch K. Novel drug and soluble target tolerant antidrug antibody assay for therapeutic antibodies bearing the P329G mutation. Bioanalysis. 2017;9:849-859 pubmed publisher
Zhang X, Olsen H, Chen S, So E, Zhou H, Burch E, et al. Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease. J Immunol. 2016;196:1165-76 pubmed publisher
McEnaney P, Fitzgerald K, Zhang A, Douglass E, Shan W, Balog A, et al. Chemically synthesized molecules with the targeting and effector functions of antibodies. J Am Chem Soc. 2014;136:18034-43 pubmed publisher
Yang Z, Ramsey J, Hamza T, Zhang Y, Li S, Yfantis H, et al. Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab. Infect Immun. 2015;83:822-31 pubmed publisher
Meuris L, Santens F, Elson G, Festjens N, Boone M, Dos Santos A, et al. GlycoDelete engineering of mammalian cells simplifies N-glycosylation of recombinant proteins. Nat Biotechnol. 2014;32:485-9 pubmed publisher
Xie J, Yamniuk A, Borowski V, Kuhn R, Susulic V, Rex Rabe S, et al. Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases. J Immunol. 2014;192:4083-92 pubmed publisher
Derer S, Glorius P, Schlaeth M, Lohse S, Klausz K, Muchhal U, et al. Increasing Fc?RIIa affinity of an Fc?RIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity. MAbs. 2014;6:409-21 pubmed publisher
Berntzen G, Andersen J, Ustgård K, Michaelsen T, Mousavi S, Qian J, et al. Identification of a high affinity FcgammaRIIA-binding peptide that distinguishes FcgammaRIIA from FcgammaRIIB and exploits FcgammaRIIA-mediated phagocytosis and degradation. J Biol Chem. 2009;284:1126-35 pubmed publisher
Richards J, Karki S, Lazar G, Chen H, Dang W, Desjarlais J. Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells. Mol Cancer Ther. 2008;7:2517-27 pubmed publisher

product information

brand :

R&D Systems

master code :

1257-FC

SKU :

1257-FC-050

product name :

Recombinant Human Fc gamma RI/CD64 Protein, CF

description :

The Recombinant Human Fc gamma RI/CD64 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Fc gamma RI/CD64 Protein, CF has been validated for the following applications: Binding Activity.

target :

Fc gamma RI/CD64

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

45-55 kDa, reducing conditions

theoretical molecular weight :

31.4 kDa

gene symbol :

FCGR1A

details of functionality :

Measured by its ability to bind human IgG with an estimated Kd 0.15 nM.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1257-FC

accessionNumbers :

P12314

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human Fc gamma RI/CD64 protein Gln16-Pro288, with a C-terminal 6-His tag

2020 USD :

349

2021 USD :

349 USD

alt names :

CD64, CD64 antigen, CD64a, CD64b, Fc fragment of IgG, high affinity Ia, receptor (CD64), FCG1, Fc-gamma receptor I B2, Fc-gamma RI, Fc-gamma RIA, FcgammaRIa, FCGR1, FCGR1B, FcgRI, FcgRIA, FCRI, FcRIA, FLJ18345, high affinity Ia, receptor for (CD64), high affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.