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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Fc gamma RI/CD64 Protein, CF
catalog :
1257-FC-050
quantity :
50 ug
price :
443 USD
more info or order :
citations: 25
Reference
xc7 apk x131 n E, Kutlu A, Y xfc ce M. Repurposing Fc gamma receptor I (FcγRI, CD64) for site-oriented monoclonal antibody capture: A proof-of-concept study for real-time detection of tumor necrosis factor-alpha (TNF -α). Heliyon. 2023;9:e19469 pubmed publisher
Torchia J, Tavares A, Carstensen L, Chen D, Huang J, Xiao T, et al. Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo. Sci Adv. 2022;8:eabq6527 pubmed publisher
An S, Yang B, Jang G, Kim D, Kim J, Oh S, et al. Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy. Nat Commun. 2022;13:5669 pubmed publisher
Rogel A, Ibrahim F, Thirdborough S, Renart Depontieu F, Birts C, Buchan S, et al. Fcγ receptor-mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies. JCI Insight. 2022;7: pubmed publisher
Kitanaga Y, Yamajuku D, Kubo S, Nakamura K, Maeda M, Seki M, et al. Discovery of a novel Igβ and FcγRIIB cross-linking antibody, ASP2713, and its potential application in the treatment of systemic lupus erythematosus. Int Immunopharmacol. 2021;101:108343 pubmed publisher
Wessel A, Doyle M, Engdahl T, Rodriguez J, Crowe J, Diamond M. Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection. MBio. 2021;12:e0244021 pubmed publisher
Aitken E, Damelang T, Ortega Pajares A, Alemu A, Hasang W, Dini S, et al. Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria. elife. 2021;10: pubmed publisher
Vanhove B, Duvaux O, Rousse J, Royer P, Evanno G, Ciron C, et al. High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2. Eur J Immunol. 2021;51:1412-1422 pubmed publisher
Zekri L, Vogt F, Osburg L, M xfc ller S, Kauer J, Manz T, et al. An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer. EMBO Mol Med. 2021;13:e11902 pubmed publisher
Wessel A, Kose N, Bombardi R, Roy V, Chantima W, Mongkolsapaya J, et al. Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy. Nat Commun. 2020;11:5278 pubmed publisher
An J, Li L, Lee J, Yu S, Kim J, Lee J, et al. Urinary cMet as a prognostic marker in immunoglobulin A nephropathy. J Cell Mol Med. 2020;24:11158-11169 pubmed publisher
Blundell P, Lu D, Wilkinson M, Dell A, Haslam S, Pleass R. Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus. J Immunol. 2019;202:1595-1611 pubmed publisher
Oshima T, Miyashita H, Ishimura Y, Ito Y, Tanaka Y, Hori A, et al. Fc engineering of anti-Nectin-2 antibody improved thrombocytopenic adverse event in monkey. PLoS ONE. 2018;13:e0196422 pubmed publisher
Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
Geuijen K, Oppers Tiemissen C, Egging D, Simons P, Boon L, Schasfoort R, et al. Rapid screening of IgG quality attributes - effects on Fc receptor binding. FEBS Open Bio. 2017;7:1557-1574 pubmed publisher
Järnum S, Runström A, Bockermann R, Winstedt L, Crispin M, Kjellman C. Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy. Mol Cancer Ther. 2017;16:1887-1897 pubmed publisher
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Zhang X, Olsen H, Chen S, So E, Zhou H, Burch E, et al. Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease. J Immunol. 2016;196:1165-76 pubmed publisher
McEnaney P, Fitzgerald K, Zhang A, Douglass E, Shan W, Balog A, et al. Chemically synthesized molecules with the targeting and effector functions of antibodies. J Am Chem Soc. 2014;136:18034-43 pubmed publisher
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product information
master code :
1257-FC
SKU :
1257-FC-050
product name :
Recombinant Human Fc gamma RI/CD64 Protein, CF
unit size :
50 ug
description :
The Recombinant Human Fc gamma RI/CD64 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Fc gamma RI/CD64 Protein, CF has been validated for the following applications: Binding Activity.
target :
Fc gamma RI/CD64
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
45-55 kDa, reducing conditions
theoretical molecular weight :
31.4 kDa
gene symbol :
FCGR1A
details of functionality :
Measured by its ability to bind human IgG with an estimated Kd 0.15 nM.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human Fc gamma RI/CD64 Protein Binding Activity
accessionNumbers :
P12314
applications :
Binding Activity
source long :
Mouse myeloma cell line, NS0-derived human Fc gamma RI/CD64 protein Gln16-Pro288, with a C-terminal 6-His tag
source short :
NS0
USD :
443 USD
alt names :
CD64, CD64 antigen, CD64a, CD64b, Fc fragment of IgG, high affinity Ia, receptor (CD64), FCG1, Fc-gamma receptor I B2, Fc-gamma RI, Fc-gamma RIA, FcgammaRIa, FCGR1, FCGR1B, FcgRI, FcgRIA, FCRI, FcRIA, FLJ18345, high affinity Ia, receptor for (CD64), high affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.