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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF
catalog :
1256-OX-050
quantity :
50 ug
price :
434 USD
more info or order :
R&D Systems product webpage
citations: 3
Reference
Zhang P, Tu G, Wei J, Santiago P, Larrabee L, Liao Chan S, et al. Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity. Cell Rep. 2019;27:3117-3123.e5 pubmed publisher
Sun G, Jin H, Zhang C, Meng H, Zhao X, Wei D, et al. OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis. Cell Rep. 2018;25:3786-3799.e4 pubmed publisher
Dollins C, Nair S, Boczkowski D, Lee J, Layzer J, Gilboa E, et al. Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. Chem Biol. 2008;15:675-82 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
1256-OX
SKU :
1256-OX-050
product name :
Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF
Description :
The Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
OX40
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Mouse
observed molecular weight :
65-75 kDa, reducing conditions
theoretical molecular weight :
48 kDa (monomer)
gene symbol :
Tnfrsf4
details of functionality :
Measured by its ability to inhibit OX40 Ligand induced IL-2 secretion by mouse T cells. The ED50 for this effect is 0.1-0.3 µg/mL in the presence of 30 ng/mL of Recombinant Mouse OX40 Ligand/TNFSF4 (Catalog # 1236-OX ).
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P47741
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein
USD :
434 USD
alt names :
ACT-135, ACT35 antigen, ACT35ATC35 antigen, CD134, CD134 antigen, Ly-70, OX40 cell surface antigen, OX40 homologue, OX40L receptor, OX40lymphoid activation antigene ACT35, TAX transcriptionally-activated glycoprotein 1 receptor, tax-transcriptionally activated glycoprotein 1 receptor, TNFRSF4, tumor necrosis factor receptor superfamily member 4, tumor necrosis factor receptor superfamily, member 4, Txgp1, TXGP1L, TXGP1LOX40 antigen
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.