Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF | R&D Systems 1256-OX-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF

catalog :

1256-OX-050

quantity :

50 ug

price :

443 USD

citations: 3

Reference
Zhang P, Tu G, Wei J, Santiago P, Larrabee L, Liao Chan S, et al. Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity. Cell Rep. 2019;27:3117-3123.e5 pubmed publisher
Sun G, Jin H, Zhang C, Meng H, Zhao X, Wei D, et al. OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis. Cell Rep. 2018;25:3786-3799.e4 pubmed publisher
Dollins C, Nair S, Boczkowski D, Lee J, Layzer J, Gilboa E, et al. Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. Chem Biol. 2008;15:675-82 pubmed publisher

product information

master code :

1256-OX

SKU :

1256-OX-050

product name :

Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse OX40/TNFRSF4 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

OX40

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

65-75 kDa, reducing conditions

theoretical molecular weight :

48 kDa (monomer)

gene symbol :

Tnfrsf4

details of functionality :

Measured by its ability to inhibit OX40 Ligand induced IL-2 secretion by mouse T cells. The ED50 for this effect is 0.1-0.3 ╡g/mL in the presence of 30 ng/mL of Recombinant Mouse OX40 Ligand/TNFSF4 (Catalog # 1236-OX ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P47741

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse OX40/TNFRSF4 protein Murine OX40 (Val20-Pro211) Accession # P47741 DIEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

source short :

NS0

USD :

443 USD

alt names :

ACT-135, ACT35 antigen, ACT35ATC35 antigen, CD134, CD134 antigen, Ly-70, OX40 cell surface antigen, OX40 homologue, OX40L receptor, OX40lymphoid activation antigene ACT35, TAX transcriptionally-activated glycoprotein 1 receptor, tax-transcriptionally activated glycoprotein 1 receptor, TNFRSF4, tumor necrosis factor receptor superfamily member 4, tumor necrosis factor receptor superfamily, member 4, Txgp1, TXGP1L, TXGP1LOX40 antigen

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.