Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein, CF | R&D Systems 1246-4L-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein, CF

catalog :

1246-4L-025/CF

quantity :

25 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Wan D, Ai S, Ouyang H, Cheng L. Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice. Exp Mol Med. 2021;53:654-666 pubmed publisher
Madireddi S, Eun S, Lee S, Nemčovičová I, Mehta A, Zajonc D, et al. Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies. J Exp Med. 2014;211:1433-48 pubmed publisher
Mahmud S, Manlove L, Schmitz H, Xing Y, Wang Y, Owen D, et al. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol. 2014;15:473-81 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1246-4L/CF

SKU :

1246-4L-025/CF

product name :

Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein, CF

Description :

The Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein, CF has been validated for the following applications: Bioactivity, Binding Activity.

target :

4-1BB Ligand/TNFSF9

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

observed molecular weight :

41-44 kDa, reducing conditions

theoretical molecular weight :

25.7 kDa

gene symbol :

Tnfsf9

details of functionality :

Measured by its ability to co-stimulate IL-2 secretion by mouse T cells in the presence of anti-CD3. The ED50 for this effect is 0.008-0.05 µg/mL in the presence of a Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050 ). Measured by its ability to bind Recombinant Mouse 4-1BB/TNFRSF9/CD137 Fc Chimera (Catalog # 937-4B ) in a functional ELISA.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P41274

applications :

Bioactivity, Binding Activity

source :

NS0-derived Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein

USD :

423 USD

alt names :

4-1BB ligand, 41BB Ligand, 4-1BBL, 4-1BB-L, CD137L, homolog of mouse 4-1BB-L, receptor 4-1BB ligand, TNFSF9, tumor necrosis factor (ligand) superfamily, member 9, tumor necrosis factor ligand superfamily member 9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage