Recombinant Mouse TWEAK/TNFSF12 Protein | R&D Systems 1237-TW-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse TWEAK/TNFSF12 Protein

catalog :

1237-TW-025

quantity :

25 ug

price :

394 USD

more info or order :

R&D Systems product webpage

citations: 13

Reference
Chen J, Jia F, Ren K, Luo M, Min X, Wang P, et al. Inhibition of suppressor of cytokine signaling 1 mediates the profibrotic effect of TWEAK/Fn14 signaling on kidney cells. Cell Signal. 2020;71:109615 pubmed publisher
da Silva S, Xu B, Maschietto M, Marchi F, Alkailani M, Bijian K, et al. TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to Anoikis. Mol Cancer Ther. 2019;18:139-146 pubmed publisher
Peng L, Li Q, Wang H, Wu J, Li C, Liu Y, et al. Fn14 deficiency ameliorates psoriasis-like skin disease in a murine model. Cell Death Dis. 2018;9:801 pubmed publisher
Hao L, Ren M, Rong B, Xie F, Lin M, Zhao Y, et al. TWEAK/Fn14 mediates atrial-derived HL-1 myocytes hypertrophy via JAK2/STAT3 signalling pathway. J Cell Mol Med. 2018;22:4344-4353 pubmed publisher
Brightbill H, Suto E, Blaquiere N, Ramamoorthi N, Sujatha Bhaskar S, Gogol E, et al. NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nat Commun. 2018;9:179 pubmed publisher
Fernández Laso V, Sastre C, Méndez Barbero N, Egido J, Martin Ventura J, Gomez Guerrero C, et al. TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice. Sci Rep. 2017;7:46679 pubmed publisher
Sasaki Y, Shimizu Y, Suzuki Y, Horikoshi S, Tomino Y. TWEAK/Fn14 system and crescent formation in IgA nephropathy. BMC Nephrol. 2015;16:27 pubmed publisher
Al Sawaf O, Fragoulis A, Rosen C, Kan Y, Sönmez T, Pufe T, et al. Nrf2 protects against TWEAK-mediated skeletal muscle wasting. Sci Rep. 2014;4:3625 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher
Dogra C, Changotra H, Wedhas N, Qin X, Wergedal J, Kumar A. TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. FASEB J. 2007;21:1857-69 pubmed
Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, et al. TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res Ther. 2006;8:R146 pubmed
Polavarapu R, Gongora M, Winkles J, Yepes M. Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation. J Neurosci. 2005;25:10094-100 pubmed

product information

brand :

R&D Systems

master code :

1237-TW

SKU :

1237-TW-025

product name :

Recombinant Mouse TWEAK/TNFSF12 Protein

description :

The Recombinant Mouse TWEAK/TNFSF12 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse TWEAK/TNFSF12 Protein has been validated for the following applications: Bioactivity.

target :

TWEAK/TNFSF12

category :

Proteins and Enzymes

sizes available :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

theoretical molecular weight :

17 kDa

gene symbol :

Tnfsf12

details of functionality :

Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 0.03-0.3 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O54907.2

applications :

Bioactivity

source :

E. coli-derived Recombinant Mouse TWEAK/TNFSF12 Protein

USD :

388

USD 2023 :

394 USD

alt names :

APO3 ligand, APO3LMGC20669, DR3LGTWEAKAPO3/DR3 ligand, MGC129581, TNF-related weak inducer of apoptosis, TNFSF12, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand superfamily member 12

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage