This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse TWEAK/TNFSF12 Protein
catalog :
1237-TW-025
quantity :
25 ug
price :
432 USD
citations: 16
Reference
Bilgic S, Domaniku A, Toledo B, Agca S, Weber B, Arabaci D, et al. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia. Nature. 2023;617:827-834 pubmed publisher
Haensel D, Dániel B, Gaddam S, Pan C, Fabo T, Bjelajac J, et al. Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche. Nat Commun. 2023;14:2685 pubmed publisher
Vesting A, Jais A, Klemm P, Steuernagel L, Wienand P, Fog Tonnesen M, et al. NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Mol Metab. 2022;66:101626 pubmed publisher
Chen J, Jia F, Ren K, Luo M, Min X, Wang P, et al. Inhibition of suppressor of cytokine signaling 1 mediates the profibrotic effect of TWEAK/Fn14 signaling on kidney cells. Cell Signal. 2020;71:109615 pubmed publisher
da Silva S, Xu B, Maschietto M, Marchi F, Alkailani M, Bijian K, et al. TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to Anoikis. Mol Cancer Ther. 2019;18:139-146 pubmed publisher
Peng L, Li Q, Wang H, Wu J, Li C, Liu Y, et al. Fn14 deficiency ameliorates psoriasis-like skin disease in a murine model. Cell Death Dis. 2018;9:801 pubmed publisher
Hao L, Ren M, Rong B, Xie F, Lin M, Zhao Y, et al. TWEAK/Fn14 mediates atrial-derived HL-1 myocytes hypertrophy via JAK2/STAT3 signalling pathway. J Cell Mol Med. 2018;22:4344-4353 pubmed publisher
Brightbill H, Suto E, Blaquiere N, Ramamoorthi N, Sujatha Bhaskar S, Gogol E, et al. NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nat Commun. 2018;9:179 pubmed publisher
Fernández Laso V, Sastre C, Méndez Barbero N, Egido J, Martin Ventura J, Gomez Guerrero C, et al. TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice. Sci Rep. 2017;7:46679 pubmed publisher
Sasaki Y, Shimizu Y, Suzuki Y, Horikoshi S, Tomino Y. TWEAK/Fn14 system and crescent formation in IgA nephropathy. BMC Nephrol. 2015;16:27 pubmed publisher
Al Sawaf O, Fragoulis A, Rosen C, Kan Y, Sönmez T, Pufe T, et al. Nrf2 protects against TWEAK-mediated skeletal muscle wasting. Sci Rep. 2014;4:3625 pubmed publisher
Freeman B, Hammarlund E, Raué H, Slifka M. Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A. 2012;109:9971-6 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher
Dogra C, Changotra H, Wedhas N, Qin X, Wergedal J, Kumar A. TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. FASEB J. 2007;21:1857-69 pubmed
Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, et al. TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res Ther. 2006;8:R146 pubmed
Polavarapu R, Gongora M, Winkles J, Yepes M. Tumor necrosis factor-like weak inducer of apoptosis increases the permeability of the neurovascular unit through nuclear factor-kappa B pathway activation. J Neurosci. 2005;25:10094-100 pubmed
product information
master code :
1237-TW
SKU :
1237-TW-025
product name :
Recombinant Mouse TWEAK/TNFSF12 Protein
unit size :
25 ug
description :
The Recombinant Mouse TWEAK/TNFSF12 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse TWEAK/TNFSF12 Protein has been validated for the following applications: Bioactivity.
target :
TWEAK/TNFSF12
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS and NaCl with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
theoretical molecular weight :
17 kDa
gene symbol :
Tnfsf12
details of functionality :
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 0.03-0.3 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O54907.2
applications :
Bioactivity
source long :
E. coli -derived mouse TWEAK/TNFSF12 protein Arg105-His249, with an N-terminal Met and a 6-His tag
source short :
E. coli
USD :
432 USD
alt names :
APO3 ligand, APO3LMGC20669, DR3LGTWEAKAPO3/DR3 ligand, MGC129581, TNF-related weak inducer of apoptosis, TNFSF12, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand superfamily member 12
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.