Recombinant Mouse OX40 Ligand/TNFSF4 Protein, CF | R&D Systems 1236-OX-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse OX40 Ligand/TNFSF4 Protein, CF

catalog :

1236-OX-025/CF

quantity :

25 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Zhang P, Tu G, Wei J, Santiago P, Larrabee L, Liao Chan S, et al. Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity. Cell Rep. 2019;27:3117-3123.e5 pubmed publisher
Sun G, Jin H, Zhang C, Meng H, Zhao X, Wei D, et al. OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis. Cell Rep. 2018;25:3786-3799.e4 pubmed publisher
Sekiya T, Hibino S, Saeki K, Kanamori M, Takaki S, Yoshimura A. Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells. Cell Rep. 2018;24:1627-1638.e6 pubmed publisher
Lei W, Zeng D, Liu G, Zhu Y, Wang J, Wu H, et al. Crucial role of OX40/OX40L signaling in a murine model of asthma. Mol Med Rep. 2018;17:4213-4220 pubmed publisher
Xiao X, Fan Y, Li J, Zhang X, Lou X, Dou Y, et al. Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation. J Exp Med. 2018;215:559-574 pubmed publisher
Arduin E, Arora S, Bamert P, Kuiper T, Popp S, Geisse S, et al. Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a. Mol Immunol. 2015;63:456-63 pubmed publisher
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, et al. TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem Biophys Res Commun. 2009;384:296-300 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

1236-OX/CF

SKU :

1236-OX-025/CF

product name :

Recombinant Mouse OX40 Ligand/TNFSF4 Protein, CF

Description :

The Recombinant Mouse OX40 Ligand/TNFSF4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse OX40 Ligand/TNFSF4 Protein, CF has been validated for the following applications: Bioactivity.

target :

OX40 Ligand/TNFSF4

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

21-25 kDa, reducing conditions

theoretical molecular weight :

18 kDa

gene symbol :

Tnfsf4

details of functionality :

Measured by its ability to co-stimulate IL-2 secretion by mouse T cells in the presence of anti-CD3. The ED50 for this effect is 10-30 ng/mL in the presence of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog # MAB050 ).

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P43488

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse OX40 Ligand/TNFSF4 Protein

USD :

423 USD

alt names :

CD134 ligand, CD134L, CD252, CD252 antigen, Glycoprotein Gp34, gp34, OX40 antigen ligand, OX40 ligand, OX40L, OX-40L, OX4OL, TAX transcriptionally-activated glycoprotein 1, tax-transcriptionally activated glycoprotein 1 (34kD), tax-transcriptionally activated glycoprotein 1, 34kD, TNFSF4, tumor necrosis factor (ligand) superfamily, member 4, tumor necrosis factor ligand superfamily member 4, TXGP1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage