product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Active ERK2 Protein, CF
catalog :
1230-KS-010
quantity :
10 ug
price :
534 USD
more info or order :
R&D Systems product webpage
citations: 5
Reference
Acharya B, Fang J, Jeffery E, Chavkin N, Genet G, Vasavada H, et al. Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest. Life Sci Alliance. 2023;6: pubmed publisher
Chen M, Wan L, Zhang J, Zhang J, Méndez L, Clohessy J, et al. Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nat Commun. 2018;9:159 pubmed publisher
Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017;543:728-732 pubmed publisher
Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, et al. IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification. J Biol Chem. 2017;292:6291-6302 pubmed publisher
Jahrling J, Hernandez C, Denner L, Dineley K. PPAR? recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement. J Neurosci. 2014;34:4054-63 pubmed publisher
image
image 1 :
R&D Systems 1230-KS-010 image 1
Recombinant Human Active ERK2 Protein SDS-PAGE
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
1230-KS
SKU :
1230-KS-010
product name :
Recombinant Human Active ERK2 Protein, CF
description :
The Recombinant Human Active ERK2 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Active ERK2 Protein, CF has been validated for the following applications: Bioactivity.
target :
ERK2
unit size :
10 ug
category :
Proteins and Enzymes
buffer :
Supplied in 50 mM Tris-HCl (pH 7.5), 150 mM NaCl, 10 mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
conjugate :
Unconjugated
purity :
>80%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane.
species :
Human
storage :
This product is stable at Avoid repeated freeze-thaw cycles.
observed molecular weight :
68 kDa
gene symbol :
MAPK1
details of functionality :
The specific activity of ERK2 was determined to be 24 nmol/min/mg using a myelin basic protein (MBP) substrate and was equivalent to 639 nmol/min/mg as per radiometric assay.
accessionNumbers :
NM_002745
applications :
Bioactivity
product keywords :
1230-KS, rhActive ERK2 Kinase, hERK2, carrier-free, carrier free, 123O-KS, 1230KS, kinasesphosphatases, ERK 2
source :
E. coli-derived Recombinant Human Active ERK2 Protein, CF
USD :
508
USD 2025 :
534 USD
alt names :
EC 2.7.11, EC 2.7.11.24, ERK, ERK-2, ERK2MAP kinase isoform p42, ERT1, Extracellular signal-regulated kinase 2, MAP kinase 1, MAP kinase 2, MAPK 1, MAPK1, MAPK2, mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, p38, p40, p41, p41mapk, p42-MAPK, P42MAPK, PRKM1, PRKM1MAPK 2, PRKM2, protein tyrosine kinase ERK2
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.