Recombinant Human PD-L2/B7-DC Fc Chimera Protein, CF | R&D Systems 1224-PL-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human PD-L2/B7-DC Fc Chimera Protein, CF

catalog :

1224-PL-100

quantity :

100 ug (also 1 mg)

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Ogishi M, Yang R, Aytekin C, Langlais D, Bourgey M, Khan T, et al. Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child. Nat Med. 2021;: pubmed publisher
Burova E, Hermann A, Waite J, Potocky T, Lai V, Hong S, et al. Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice. Mol Cancer Ther. 2017;16:861-870 pubmed publisher
Azoulay Alfaguter I, Strazza M, Pedoeem A, Mor A. The coreceptor programmed death 1 inhibits T-cell adhesion by regulating Rap1. J Allergy Clin Immunol. 2015;135:564-7 pubmed publisher
Steidl C, Shah S, Woolcock B, Rui L, Kawahara M, Farinha P, et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature. 2011;471:377-81 pubmed publisher

product information

brand :

R&D Systems

master code :

1224-PL

SKU :

1224-PL-100

product name :

Recombinant Human PD-L2/B7-DC Fc Chimera Protein, CF

unit size :

100 ug (also 1 mg)

seo description :

The Recombinant Human PD-L2/B7-DC Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human PD-L2/B7-DC Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

PD-L2/B7-DC

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Binding Activity

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

70-80 kDa, reducing conditions

theoretical molecular weight :

49 kDa (monomer)

gene symbol :

PDCD1LG2

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized recombinant human (rh) PD-L2 at 1 ╡g/mL (100 ╡L/well) can bind rhPD-1 with a linear range of 7.5-500 ng/mL.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

top caption :

Surface plasmon resonance sensorgram of human PD-L2 protein binding to human PD-1

accessionNumbers :

Q9BQ51.2

applications :

Binding Activity

source :

NS0-derived Recombinant Human PD-L2/B7-DC Fc Chimera Protein, CF

USD :

400 USD

alt names :

B7-DC, bA574F11.2, Btdc, Butyrophilin B7-DC, Butyrophilin-like Protein, CD273, CD273 antigen, CD273PD-1 ligand 2, MGC142240, PD-1-ligand 2, PDCD1L2MGC142238, PDCD1LG2, PDL2, PDL2B7DC, PD-L2PDCD1 ligand 2, programmed cell death 1 ligand 2, Programmed death ligand 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage