Recombinant Mouse IL-18 BPd Fc Chimera Protein, CF | R&D Systems 122-BP-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IL-18 BPd Fc Chimera Protein, CF

catalog :

122-BP-100

quantity :

100 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Menachem A, Alteber Z, Cojocaru G, Fridman Kfir T, Blat D, Leiderman O, et al. Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects. Cancer Immunol Res. 2024;12:687-703 pubmed publisher
Lê V, Dubois J, Couture C, Cavanagh M, Uyar O, Pizzorno A, et al. Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice. PLoS Pathog. 2019;15:e1007689 pubmed publisher
Jelencic V, Šestan M, Kavazović I, Lenartic M, Marinović S, Holmes T, et al. NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development. Nat Immunol. 2018;19:1083-1092 pubmed publisher
Arifa R, Madeira M, de Paula T, Lima R, Tavares L, Menezes Garcia Z, et al. Inflammasome activation is reactive oxygen species dependent and mediates irinotecan-induced mucositis through IL-1? and IL-18 in mice. Am J Pathol. 2014;184:2023-34 pubmed publisher
Ma Y, Aymeric L, Locher C, Mattarollo S, Delahaye N, Pereira P, et al. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med. 2011;208:491-503 pubmed publisher
Chandrasekar B, Patel D, Mummidi S, Kim J, Clark R, Valente A. Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. J Biol Chem. 2008;283:4200-9 pubmed
Wang X, Hagberg H, Mallard C, Zhu C, Hedtjarn M, Tiger C, et al. Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine inflammation. Am J Pathol. 2006;169:967-76 pubmed
Kim B, Lee S, Suvas S, Rouse B. Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. J Immunol. 2005;175:509-16 pubmed

product information

master code :

122-BP

SKU :

122-BP-100

product name :

Recombinant Mouse IL-18 BPd Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Mouse IL-18 BPd Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IL-18 BPd Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-18 BPd

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

60-70 kDa, reducing conditions

theoretical molecular weight :

44.5 kDa (monomer)

gene symbol :

Il18bp

details of functionality :

Measured by its ability to inhibit the IL-18-induced response of mouse Tácells. The ED50 for this effect is 0.1-0.4 ╡g/mL in the presence of 0.5 ng/mL of rmIL-18.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAD17194

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived mouse IL-18 BPd protein Mouse IL-18 BPd/Fc (Thr27 - Ala191) (Ala29 - Ala191) Accession # AAD17194 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage