product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human FGF-3 Protein
catalog :
1206-F3-025
quantity :
25 ug
price :
480 USD
more info or order :
R&D Systems product webpage
citations: 14
Reference
Chen Y, Mu W, Wu Y, Xu J, Li X, Hu H, et al. Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei. J Tissue Eng. 2024;15:20417314241265198 pubmed publisher
K xf8 murcu K, Wilhelmsen I, Thorne J, Krauss S, Wilson S, Aizenshtadt A, et al. Mass spectrometry reveals that oxysterols are secreted from non-alcoholic fatty liver disease induced organoids. J Steroid Biochem Mol Biol. 2023;232:106355 pubmed publisher
Saeki T, Yoshimatsu S, Ishikawa M, Hon C, Koya I, Shibata S, et al. Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish. Regen Ther. 2022;20:165-186 pubmed publisher
Cui L, Zheng J, Zhao Q, Chen J, Liu H, Peng G, et al. Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss. JCI Insight. 2020;5: pubmed publisher
Boddy S, Romero Guevara R, Ji A, Unger C, Corns L, Marcotti W, et al. Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs. Stem Cells Int. 2020;2020:3692937 pubmed publisher
Westphal S, Gantert T, Kless C, Hüttinger K, Klingenspor M, Fromme T. Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes. Sci Rep. 2019;9:8470 pubmed publisher
Lahlou H, Lopez Juarez A, Fontbonne A, Nivet E, Zine A. Modeling human early otic sensory cell development with induced pluripotent stem cells. PLoS ONE. 2018;13:e0198954 pubmed publisher
Zhong C, Chen Z, Luo X, Wang C, Jiang H, Shao J, et al. Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells. Int J Biochem Cell Biol. 2018;96:79-89 pubmed publisher
Hanker A, Garrett J, Estrada M, Moore P, Ericsson P, Koch J, et al. HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2. Clin Cancer Res. 2017;23:4323-4334 pubmed publisher
Dalle Nogare D, Somers K, Rao S, Matsuda M, Reichman Fried M, Raz E, et al. Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordium. Development. 2014;141:3188-96 pubmed publisher
Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, et al. Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10. Mol Cell Biol. 2014;34:2848-56 pubmed publisher
Mann Z, Thiede B, Chang W, Shin J, May Simera H, Lovett M, et al. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun. 2014;5:3839 pubmed publisher
Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher
Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, et al. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008;283:23139-49 pubmed publisher
product information
brand :
R&D Systems
master code :
1206-F3
SKU :
1206-F3-025
product name :
Recombinant Human FGF-3 Protein
unit size :
25 ug
seo description :
The Recombinant Human FGF-3 Protein from R&D Systems is derived from E. coli. The Recombinant Human FGF-3 Protein has been validated for the following applications: Bioactivity.
target :
FGF-3
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in MOPS, Na2SO4, TCEP and EDTA with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
theoretical molecular weight :
21.1 kDa
gene symbol :
FGF3
details of functionality :
Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Rizzino, A. et al . (1988) Cancer Res. 48 :4266; Thomas, K. et al . (1987) Methods Enzymol. 147 :120. The ED50 for this effect is 0.02-0.1 ╡g/mL in the presence of 1 ╡g/mL of heparin.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
NP_005238
applications :
Bioactivity
source :
E. coli-derived Recombinant Human FGF-3 Protein
USD :
480 USD
alt names :
FGF3, fibroblast growth factor 3, fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog), HBGF-3, Hst, INT-2, mouse, oncogene INT2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.