Recombinant Human Cystatin C Protein, CF | R&D Systems 1196-PI product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Cystatin C Protein, CF

catalog :

1196-PI

quantity :

10 ug

price :

339 USD

citations: 6

Reference
Zhang Y, Vernooij F, Ibrahim I, Ooi S, Gijsberts C, Schoneveld A, et al. Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort. PLoS ONE. 2016;11:e0148073 pubmed publisher
Kasabova M, Joulin Giet A, Lecaille F, Gilmore B, Marchand Adam S, Saidi A, et al. Regulation of TGF-?1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C. J Biol Chem. 2014;289:16239-51 pubmed publisher
Naudin C, Joulin Giet A, Couetdic G, Plesiat P, Szymanska A, Gorna E, et al. Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis. PLoS ONE. 2011;6:e25577 pubmed publisher
Feldman A, Banyard J, Wu C, McDougal W, Zetter B. Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. Clin Cancer Res. 2009;15:1024-31 pubmed publisher
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed
Johnson G, Jiang W. Characterization of cathepsin L secreted by Sf21 insect cells. Arch Biochem Biophys. 2005;444:7-14 pubmed

product information

brand :

R&D Systems

master code :

1196-PI

SKU :

1196-PI-010

product name :

Recombinant Human Cystatin C Protein, CF

description :

The Recombinant Human Cystatin C Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cystatin C Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Cystatin C

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in HEPES and NaCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

17 kDa, reducing conditions

theoretical molecular weight :

15 kDa

gene symbol :

CST3

details of functionality :

Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC (Catalog # ES009 ). The IC50 value is 12 nM, under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1196-PI

accessionNumbers :

P01034.1

applications :

Inhibition Activity

source :

Mouse myeloma cell line, NS0-derived human Cystatin C protein Met1-Ala146, with a C-terminal 10-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

ARMD11, bA218C14.4 (cystatin C), CST3, cystatin 3, cystatin C, cystatin C (amyloid angiopathy and cerebral hemorrhage), cystatin-3, cystatin-C, Gamma-trace, MGC117328, Neuroendocrine basic polypeptide, Post-gamma-globulin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.