product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Cystatin C Protein, CF
catalog :
1196-PI-010
quantity :
10 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 6
Reference
Zhang Y, Vernooij F, Ibrahim I, Ooi S, Gijsberts C, Schoneveld A, et al. Extracellular Vesicle Proteins Associated with Systemic Vascular Events Correlate with Heart Failure: An Observational Study in a Dyspnoea Cohort. PLoS ONE. 2016;11:e0148073 pubmed publisher
Kasabova M, Joulin Giet A, Lecaille F, Gilmore B, Marchand Adam S, Saidi A, et al. Regulation of TGF-?1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C. J Biol Chem. 2014;289:16239-51 pubmed publisher
Naudin C, Joulin Giet A, Couetdic G, Plesiat P, Szymanska A, Gorna E, et al. Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis. PLoS ONE. 2011;6:e25577 pubmed publisher
Feldman A, Banyard J, Wu C, McDougal W, Zetter B. Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. Clin Cancer Res. 2009;15:1024-31 pubmed publisher
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed
Johnson G, Jiang W. Characterization of cathepsin L secreted by Sf21 insect cells. Arch Biochem Biophys. 2005;444:7-14 pubmed
product information
brand :
R&D Systems
master code :
1196-PI
SKU :
1196-PI-010
product name :
Recombinant Human Cystatin C Protein, CF
unit size :
10 ug
seo description :
The Recombinant Human Cystatin C Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cystatin C Protein, CF has been validated for the following applications: Inhibition Activity.
target :
Cystatin C
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in HEPES and NaCl.
conjugate :
Unconjugated
dilution :
Inhibition Activity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
17 kDa, reducing conditions
theoretical molecular weight :
15 kDa
gene symbol :
CST3
details of functionality :
Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC (Catalog # ES009 ). The IC50 value is 12 nM, under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P01034.1
applications :
Inhibition Activity
source :
NS0-derived Recombinant Human Cystatin C Protein, CF
USD :
432 USD
alt names :
ARMD11, bA218C14.4 (cystatin C), CST3, cystatin 3, cystatin C, cystatin C (amyloid angiopathy and cerebral hemorrhage), cystatin-3, cystatin-C, Gamma-trace, MGC117328, Neuroendocrine basic polypeptide, Post-gamma-globulin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.