Recombinant Human Epiregulin Protein, CF | R&D Systems 1195-EP-025/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Epiregulin Protein, CF

catalog :

1195-EP-025/CF

quantity :

25 ug

price :

407 USD

citations: 7

Reference
Lemmetyinen T, Viitala E, Wartiovaara L, Kaprio T, Hagstr xf6 m J, Haglund C, et al. Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth. Dis Model Mech. 2023;16: pubmed publisher
Song N, Lee A, Yasmeen R, Shen Q, Yang K, Kumar S, et al. Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in Obesity. Cells. 2022;11: pubmed publisher
Liu S, Wang Y, Han Y, Xia W, Zhang L, Xu S, et al. EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy. Theranostics. 2020;10:10589-10605 pubmed publisher
Iijima M, Anai M, Kodama T, Shibasaki Y. Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling. Biochem Biophys Res Commun. 2017;489:83-88 pubmed publisher
Blaha M, Nemcova L, Kepková K, Vodicka P, Prochazka R. Gene expression analysis of pig cumulus-oocyte complexes stimulated in vitro with follicle stimulating hormone or epidermal growth factor-like peptides. Reprod Biol Endocrinol. 2015;13:113 pubmed publisher
Auf G, Jabouille A, Delugin M, Guérit S, Pineau R, North S, et al. High epiregulin expression in human U87 glioma cells relies on IRE1? and promotes autocrine growth through EGF receptor. BMC Cancer. 2013;13:597 pubmed publisher
Armant D, Kilburn B, Petkova A, Edwin S, Duniec Dmuchowski Z, Edwards H, et al. Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor. Development. 2006;133:751-9 pubmed

product information

master code :

1195-EP/CF

SKU :

1195-EP-025/CF

product name :

Recombinant Human Epiregulin Protein, CF

unit size :

25 ug

description :

The Recombinant Human Epiregulin Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Epiregulin Protein, CF has been validated for the following applications: Bioactivity.

target :

Epiregulin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

5.4 kDa

gene symbol :

EREG

details of functionality :

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al . (1991) Proc. Natl. Acad. Sci. USA 88 :415. The ED50 for this effect is 0.125-0.75 ng/mL.

endotoxin note :

<0.1 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human Epiregulin Protein Bioactivity

accessionNumbers :

O14944

applications :

Bioactivity

source long :

E. coli -derived human Epiregulin protein Val63-Leu108, with an N-terminal Met

source short :

E. coli

USD :

407 USD

alt names :

epiregulin, ER, EREG, proepiregulin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.