This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-18 BPa Fc Chimera Protein, CF
catalog :
119-BP
quantity :
100 ug
price :
359 USD
citations: 10
Reference
Weiss E, Girard Guyonvarc h C, Holzinger D, de Jesus A, Tariq Z, Picarsic J, et al. Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood. 2018;131:1442-1455 pubmed publisher
Briend E, Ferguson G, Mori M, Damera G, Stephenson K, Karp N, et al. IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD. Respir Res. 2017;18:159 pubmed publisher
Zannetti C, Roblot G, Charrier E, Ainouze M, Tout I, Briat F, et al. Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens. J Immunol. 2016;197:356-67 pubmed publisher
Sutinen E, Pirttila T, Anderson G, Salminen A, Ojala J. Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-? production in human neuron-like cells. J Neuroinflammation. 2012;9:199 pubmed
Valente A, Yoshida T, Murthy S, Sakamuri S, Katsuyama M, Clark R, et al. Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18. Am J Physiol Heart Circ Physiol. 2012;303:H282-96 pubmed publisher
Venkatesan B, Valente A, Reddy V, Siwik D, Chandrasekar B. Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration. Am J Physiol Heart Circ Physiol. 2009;297:H874-86 pubmed publisher
Chandrasekar B, Boylston W, Venkatachalam K, Webster N, Prabhu S, Valente A. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem. 2008;283:24889-98 pubmed publisher
Nazarian S, Rahman M, Werden S, Villeneuve D, Meng X, Brunetti C, et al. Yaba monkey tumor virus encodes a functional inhibitor of interleukin-18. J Virol. 2008;82:522-8 pubmed publisher
Felderhoff Mueser U, Sifringer M, Polley O, Dzietko M, Leineweber B, Mahler L, et al. Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Ann Neurol. 2005;57:50-9 pubmed
Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, et al. IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. J Immunol. 2003;170:5571-7 pubmed
product information
brand :
R&D Systems
master code :
119-BP
SKU :
119-BP-100
product name :
Recombinant Human IL-18 BPa Fc Chimera Protein, CF
description :
The Recombinant Human IL-18 BPa Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-18 BPa Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
IL-18 BPa/IL18BP
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
60-80 kDa, reducing conditions
theoretical molecular weight :
44.2 kDa (monomer)
gene symbol :
IL18BP
details of functionality :
Measured by its ability to inhibit the IL-18-induced response of KG-1 human acute myelogenous leukemia cells. The ED50 for this effect is 0.02-0.12 µg/mL in the presence of 40 ng/mL of recombinant human IL-18.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
119-BP
accessionNumbers :
AAD17190
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human IL-18 BPa protein Human IL-18 Bpa (Thr29-Gly192) Accession # AAD17190 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
2020 USD :
359
2021 USD :
359 USD
alt names :
IL18 BPa, IL18BP, IL-18BP, IL18BPa, interleukin 18 binding protein, interleukin-18-binding protein, MC51L-53L-54L homolog gene product, tadekinig-alfa
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.