Recombinant Human IL-18 BPa Fc Chimera Protein, CF | R&D Systems 119-BP-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-18 BPa Fc Chimera Protein, CF

catalog :

119-BP-100

quantity :

100 ug

price :

425 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Menachem A, Alteber Z, Cojocaru G, Fridman Kfir T, Blat D, Leiderman O, et al. Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects. Cancer Immunol Res. 2024;12:687-703 pubmed publisher
Cui W, Hull L, Zizzo A, Wang L, Lin B, Zhai M, et al. The Roles of IL-18 in a Realistic Partial Body Irradiation with 5% Bone Marrow Sparing (PBI/BM5) Model. Toxics. 2023;12: pubmed publisher
Cui W, Hull L, Zizzo A, Wang L, Lin B, Zhai M, et al. Pharmacokinetic Study of rhIL-18BP and Its Effect on Radiation-Induced Cytokine Changes in Mouse Serum and Intestine. Toxics. 2022;11: pubmed publisher
Nayrac M, Requena M, Loiseau C, Cazabat M, Suc B, Carrere N, et al. Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals. Mucosal Immunol. 2021;14:219-228 pubmed publisher
Weiss E, Girard Guyonvarc h C, Holzinger D, de Jesus A, Tariq Z, Picarsic J, et al. Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood. 2018;131:1442-1455 pubmed publisher
Briend E, Ferguson G, Mori M, Damera G, Stephenson K, Karp N, et al. IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD. Respir Res. 2017;18:159 pubmed publisher
Zannetti C, Roblot G, Charrier E, Ainouze M, Tout I, Briat F, et al. Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens. J Immunol. 2016;197:356-67 pubmed publisher
Sutinen E, Pirttila T, Anderson G, Salminen A, Ojala J. Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-? production in human neuron-like cells. J Neuroinflammation. 2012;9:199 pubmed
Venkatesan B, Valente A, Reddy V, Siwik D, Chandrasekar B. Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration. Am J Physiol Heart Circ Physiol. 2009;297:H874-86 pubmed publisher
Nazarian S, Rahman M, Werden S, Villeneuve D, Meng X, Brunetti C, et al. Yaba monkey tumor virus encodes a functional inhibitor of interleukin-18. J Virol. 2008;82:522-8 pubmed publisher
Felderhoff Mueser U, Sifringer M, Polley O, Dzietko M, Leineweber B, Mahler L, et al. Caspase-1-processed interleukins in hyperoxia-induced cell death in the developing brain. Ann Neurol. 2005;57:50-9 pubmed
Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, et al. IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. J Immunol. 2003;170:5571-7 pubmed

product information

brand :

R&D Systems

master code :

119-BP

SKU :

119-BP-100

product name :

Recombinant Human IL-18 BPa Fc Chimera Protein, CF

unit size :

100 ug

seo description :

The Recombinant Human IL-18 BPa Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IL-18 BPa Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-18 BPa

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

60-80 kDa, reducing conditions

theoretical molecular weight :

44.2 kDa (monomer)

gene symbol :

IL18BP

details of functionality :

Measured by its ability to inhibit the IL-18-induced response of KG-1 human acute myelogenous leukemia cells. The ED50 for this effect is 0.02-0.12 ╡g/mL in the presence of 40 ng/mL of recombinant human IL-18.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAD17190

applications :

Bioactivity

source :

NS0-derived Recombinant Human IL-18 BPa Fc Chimera Protein, CF

USD :

425 USD

alt names :

IL18 BPa, IL18BP, IL-18BP, IL18BPa, interleukin 18 binding protein, interleukin-18-binding protein, MC51L-53L-54L homolog gene product, tadekinig-alfa

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage