Recombinant Human JAM-C Fc Chimera Protein, CF | R&D Systems 1189-J3 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human JAM-C Fc Chimera Protein, CF

catalog :

1189-J3

quantity :

50 ug

price :

339 USD

citations: 3

Reference
Wolf D, Anto Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann J, et al. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nat Commun. 2018;9:525 pubmed publisher
Arcangeli M, Bardin F, Frontera V, Bidaut G, Obrados E, Adams R, et al. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. Stem Cells. 2014;32:1043-54 pubmed publisher
Zen K, Babbin B, Liu Y, Whelan J, Nusrat A, Parkos C. JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. Mol Biol Cell. 2004;15:3926-37 pubmed

product information

brand :

R&D Systems

master code :

1189-J3

SKU :

1189-J3-050

product name :

Recombinant Human JAM-C Fc Chimera Protein, CF

description :

The Recombinant Human JAM-C Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human JAM-C Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

JAM-C

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Tris-Citrate and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

60-65 kDa, reducing conditions

theoretical molecular weight :

50 kDa (monomer)

gene symbol :

JAM3

details of functionality :

Measured by its ability to inhibit the adhesion of J45.01 human acute lymphoblastic leukemia T lymphocytes on immobilized JAM-2 (VE-JAM)/Fc Chimera. When 0.2 µg/mL (100 µL/well) of rhJAM-B/Fc Chimera is immobilized on goat anti-human IgG Fc Chimera antibody coated wells, the ED50 for this effect is 0.1-0.5 µg/mL in the presence of 1 x 105 cells/well.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

1189-J3

accessionNumbers :

Q9BX67

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human JAM-C protein Human JAM-C Val32 - Asn241 (Ala149Pro) Accession # Q9BX67 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

2020 USD :

339

2021 USD :

339 USD

alt names :

CD323, JAM-2, JAM3, JAMC, JAM-CFLJ14529, junctional adhesion molecule 3JAM-3, junctional adhesion molecule C

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.