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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Cathepsin S Protein, CF
catalog :
1183-CY-010
quantity :
10 ug
price :
432 USD
more info or order :
citations: 18
Reference
Zisman D, Sabtan H, Rahat M, Simanovich E, Haddad A, Gazitt T, et al. Tofacitinib Regulates Endostatin via Effects on CD147 and Cathepsin S. Int J Mol Sci. 2024;25: pubmed publisher
Smyth P, Ferguson L, Burrows J, Burden R, Tracey S, Herron x, et al. Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy. Front Pharmacol. 2023;14:1296567 pubmed publisher
Luebben A, Bender D, Becker S, Crowther L, Erven I, Hofmann K, et al. Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration. Sci Adv. 2022;8:eabj8633 pubmed publisher
Falkowski P, Mrozek P, Lukaszewski Z, Oldak L, Gorodkiewicz E. An Immunosensor for the Determination of Cathepsin S in Blood Plasma by Array SPRi-A Comparison of Analytical Properties of Silver-Gold and Pure Gold Chips. Biosensors (Basel). 2021;11: pubmed publisher
Flynn C, Garbers Y, Düsterhöft S, Wichert R, Lokau J, Lehmann C, et al. Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro. Sci Rep. 2020;10:21612 pubmed publisher
Høglund R, Torsetnes S, Lossius A, Bogen B, Homan E, BREMEL R, et al. Human Cysteine Cathepsins Degrade Immunoglobulin G In Vitro in a Predictable Manner. Int J Mol Sci. 2019;20: pubmed publisher
Blau R, Epshtein Y, Pisarevsky E, Tiram G, Israeli Dangoor S, Yeini E, et al. Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins. Theranostics. 2018;8:3437-3460 pubmed publisher
Schaal J, Tran D, Subramanian A, Patel R, Laragione T, Roberts K, et al. Suppression and resolution of autoimmune arthritis by rhesus ?-defensin-1, an immunomodulatory macrocyclic peptide. PLoS ONE. 2017;12:e0187868 pubmed publisher
Takayama F, Zhang X, Hayashi Y, Wu Z, Nakanishi H. Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice. Biochem Biophys Res Commun. 2017;490:447-452 pubmed publisher
Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella F, et al. Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med. 2016;22:1140-1150 pubmed publisher
Jiang H, Cheng X, Shi G, Hu L, Inoue A, Yamamura Y, et al. Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia. Nat Commun. 2014;5:3838 pubmed publisher
Guery L, Benikhlef N, Gautier T, Paul C, Jego G, Dufour E, et al. Fine-tuning nucleophosmin in macrophage differentiation and activation. Blood. 2011;118:4694-704 pubmed publisher
Zou F, Schäfer N, Palesch D, Brücken R, Beck A, Sienczyk M, et al. Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients. PLoS ONE. 2011;6:e22815 pubmed publisher
Schipper H, de Jager W, van Dijk M, Meerding J, Zelissen P, Adan R, et al. A multiplex immunoassay for human adipokine profiling. Clin Chem. 2010;56:1320-8 pubmed publisher
Burster T, Marin Esteban V, Boehm B, Dunn S, Rotzschke O, Falk K, et al. Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions. Biochem Pharmacol. 2007;74:1514-23 pubmed
Barkho B, Song H, Aimone J, Smrt R, Kuwabara T, Nakashima K, et al. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006;15:407-21 pubmed
Cheng T, Hitomi K, van Vlijmen Willems I, de Jongh G, Yamamoto K, Nishi K, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem. 2006;281:15893-9 pubmed
Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, et al. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 2006;20:543-56 pubmed
product information
brand :
R&D Systems
master code :
1183-CY
SKU :
1183-CY-010
product name :
Recombinant Human Cathepsin S Protein, CF
unit size :
10 ug
seo description :
The Recombinant Human Cathepsin S Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Cathepsin S Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Cathepsin S
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in MES, NaCl and Glycerol.
conjugate :
Unconjugated
dilution :
Enzyme Activity
species :
Human
observed molecular weight :
37-41 kDa and 26-27 kDa, reducing conditions
theoretical molecular weight :
39 kDa (Pro) and 28 kDa (mature)
gene symbol :
CTSS
details of functionality :
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog # ES002 ). The specific activity is 300 pmol/min/╡g, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P25774
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human Cathepsin S Protein, CF
USD :
432 USD
alt names :
cathepsin S, CTSS, EC 3.4.22, EC 3.4.22.27, FLJ50259, MGC3886
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.