Recombinant Human Neprilysin (CHO-expressed) Protein, CF | R&D Systems 1182-ZNC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Neprilysin (CHO-expressed) Protein, CF

catalog :

1182-ZNC

quantity :

10 ug

price :

339 USD

citations: 5

Reference
Takeuchi M, Okamoto M, Okamoto R, Kinoshita H, Yamaguchi Y, Watanabe N. Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity. Peptides. 2018;102:8-15 pubmed publisher
Mora Huertas A, Schmelzer C, Luise C, Sippl W, Pietzsch M, Hoehenwarter W, et al. Degradation of tropoelastin and skin elastin by neprilysin. Biochimie. 2018;146:73-78 pubmed publisher
Humpel C. Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques. Front Aging Neurosci. 2015;7:47 pubmed publisher
Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, et al. Lentivirus mediated delivery of neurosin promotes clearance of wild-type ?-synuclein and reduces the pathology in an ?-synuclein model of LBD. Mol Ther. 2013;21:31-41 pubmed publisher
Lan X, Xu J, Kiyota T, Peng H, Zheng J, Ikezu T. HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. J Immunol. 2011;186:6925-32 pubmed publisher

product information

brand :

R&D Systems

master code :

1182-ZNC

SKU :

1182-ZNC-010

product name :

Recombinant Human Neprilysin (CHO-expressed) Protein, CF

description :

The Recombinant Human Neprilysin (CHO-expressed) Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Neprilysin (CHO-expressed) Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Neprilysin/CD10

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris, NaCl and ZnCl2.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

102 kDa, reducing conditions

theoretical molecular weight :

81 kDa

gene symbol :

MME

details of functionality :

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH (Catalog # ES005 ). The specific activity is 1,500 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

1182-ZNC

accessionNumbers :

P08473

applications :

Enzyme Activity

source :

Chinese Hamster Ovary cell line, CHO-derived human Neprilysin/CD10 protein Tyr52-Trp750, with an N-terminal 6-His tag

2020 USD :

339

2021 USD :

339 USD

alt names :

Atriopeptidase, CALLA, CALLAmembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase), CD10, CD10 antigen, CD10), CD10membrane metallo-endopeptidase variant 1, Common acute lymphocytic leukemia antigen, DKFZp686O16152, EC 3.4.24, EC 3.4.24.11, Enkephalinase, EPN, Leu-19, membrane metallo-endopeptidase, membrane metallo-endopeptidase variant 2, MGC126681, MGC126707, MME, NEPmembrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, neprilysin, Neutral endopeptidase, Neutral Endopeptidase 24.11, NKH1, SFE, Skin fibroblast elastase

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.