product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse RAGE Fc Chimera Protein, CF
catalog :
1179-RG-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 9
Reference
Zhang F, Su X, Huang G, Xin X, Cao E, Shi Y, et al. sRAGE alleviates neutrophilic asthma by blocking HMGB1/RAGE signalling in airway dendritic cells. Sci Rep. 2017;7:14268 pubmed publisher
Blondonnet R, Audard J, Belville C, Clairefond G, Lutz J, Bouvier D, et al. RAGE inhibition reduces acute lung injury in mice. Sci Rep. 2017;7:7208 pubmed publisher
Gao Y, Bielohuby M, Fleming T, Grabner G, Foppen E, Bernhard W, et al. Dietary sugars, not lipids, drive hypothalamic inflammation. Mol Metab. 2017;6:897-908 pubmed publisher
Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B. Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. J Biol Chem. 2016;291:12057-73 pubmed publisher
Biedroń R, Konopiński M, Marcinkiewicz J, Józefowski S. Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages. PLoS ONE. 2015;10:e0123293 pubmed publisher
Mizumoto S, Takahashi J, Sugahara K. Receptor for advanced glycation end products (RAGE) functions as receptor for specific sulfated glycosaminoglycans, and anti-RAGE antibody or sulfated glycosaminoglycans delivered in vivo inhibit pulmonary metastasis of tumor cells. J Biol Chem. 2012;287:18985-94 pubmed publisher
Kuhla A, Hettwer C, Menger M, Vollmar B. Oxidative stress-associated rise of hepatic protein glycation increases inflammatory liver injury in uncoupling protein-2 deficient mice. Lab Invest. 2010;90:1189-98 pubmed publisher
Su X, Looney M, Gupta N, Matthay M. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1-5 pubmed publisher
Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen M, et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med. 2007;13:1042-9 pubmed
product information
brand :
R&D Systems
master code :
1179-RG
SKU :
1179-RG-050
product name :
Recombinant Mouse RAGE Fc Chimera Protein, CF
unit size :
50 ug
seo description :
The Recombinant Mouse RAGE Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse RAGE Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
RAGE/AGER
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
observed molecular weight :
80-85 kDa, reducing conditions
theoretical molecular weight :
60.5 kDa (monomer)
gene symbol :
Ager
details of functionality :
Measured by its binding ability in a functional ELISA. rmRAGE/Fc Chimera immobilized at 5 ╡g/mL (100 ╡L/well) on a goat anti-human IgG Fc antibody-coated plate (0.5 ╡g/well) can bind biotinylated advanced glycation endproducts of bovine serum albumin (AGE-BSA, Catalog # BT4127) with a linear range of 0.02-1 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
O35444
applications :
Binding Activity
source :
NS0-derived Recombinant Mouse RAGE Fc Chimera Protein, CF
USD :
432 USD
alt names :
advanced glycosylation end product-specific receptor, AGER, RAGE isoform delta, RAGE isoform sRAGE-delta, Receptor for advanced glycosylation end products, receptor for advanced glycosylation end-products, SCARJ1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.