Recombinant Viral HCMV IL-10 Protein | R&D Systems 117-VL-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Viral HCMV IL-10 Protein

catalog :

117-VL-025

quantity :

25 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 11

Reference
Veld L, Waters S, Irish A, Price P, Lee S. An IL-10 homologue encoded by human cytomegalovirus is linked with the viral "footprint" in clinical samples. Cytokine. 2024;180:156654 pubmed publisher
Waters S, Lee S, Irish A, Price P. Challenging the Conventional Interpretation of HCMV Seronegativity. Microorganisms. 2021;9: pubmed publisher
Valle Oseguera C, Spencer J. Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells. Cancer Cell Int. 2017;17:24 pubmed publisher
Stuchly J, Kanderová V, Vlkova M, Hermanova I, Slamova L, Pelak O, et al. Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia. Sci Rep. 2017;7:39710 pubmed publisher
Bishop R, Valle Oseguera C, Spencer J. Human Cytomegalovirus interleukin-10 promotes proliferation and migration of MCF-7 breast cancer cells. Cancer Cell Microenviron. 2015;2: pubmed
Valle Oseguera C, Spencer J. cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells. PLoS ONE. 2014;9:e88708 pubmed publisher
Forster S, Brandt M, Mottok D, Zschüttig A, Zimmermann K, Blattner F, et al. Secretory expression of biologically active human Herpes virus interleukin-10 analogues in Escherichia coli via a modified Sec-dependent transporter construct. BMC Biotechnol. 2013;13:82 pubmed publisher
Dziurzynski K, Wei J, Qiao W, Hatiboglu M, Kong L, Wu A, et al. Glioma-associated cytomegalovirus mediates subversion of the monocyte lineage to a tumor propagating phenotype. Clin Cancer Res. 2011;17:4642-9 pubmed publisher
Chang W, Barry P, Szubin R, Wang D, Baumgarth N. Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog. Virology. 2009;390:330-7 pubmed publisher
van Putten S, Wubben M, Hennink W, van Luyn M, Harmsen M. The downmodulation of the foreign body reaction by cytomegalovirus encoded interleukin-10. Biomaterials. 2009;30:730-5 pubmed publisher
Gruber S, Gloria Luciani M, Grundtner P, Zdanov A, Gasche C. Differential signaling of cmvIL-10 through common variants of the IL-10 receptor 1. Eur J Immunol. 2008;38:3365-75 pubmed publisher

product information

brand :

R&D Systems

master code :

117-VL

SKU :

117-VL-025

product name :

Recombinant Viral HCMV IL-10 Protein

unit size :

25 ug

seo description :

The Recombinant Viral HCMV IL-10 Protein from R&D Systems is derived from E. coli. The Recombinant Viral HCMV IL-10 Protein has been validated for the following applications: Bioactivity.

target :

IL-10

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in NaH2PO4 and NaCl with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Viral

theoretical molecular weight :

17.6 kDa

gene symbol :

CeHV15gBCRF1

details of functionality :

Measured by its ability to inhibit LPS-induced IL-1▀ secretion by human peripheral blood lymphocytes (PBL). The ED50 for this effect is 0.1-0.6 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAF63437

applications :

Bioactivity

source :

E. coli-derived Recombinant Viral HCMV IL-10 Protein

USD :

456 USD

alt names :

CSIF, CSIFMGC126450, Cytokine synthesis inhibitory factor, GVHDS, IL10, IL10A, IL-10MGC126451, interleukin 10, interleukin-10, TGIF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage