product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse sFRP-2 Protein
catalog :
1169-FR-025
quantity :
25 ug
price :
498 USD
more info or order :
R&D Systems product webpage
citations: 12
Reference
Shimizu K, Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, et al. Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction. Nat Commun. 2023;14:4417 pubmed publisher
Ramos Fernández E, Arrázola M, Oliva C, Arredondo S, Varela Nallar L, Inestrosa N. Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase. Sci Rep. 2021;11:7395 pubmed publisher
Montagner M, Bhome R, Hooper S, Chakravarty P, Qin X, Sufi J, et al. Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination. Nat Cell Biol. 2020;22:289-296 pubmed publisher
Chen C, Yang Y, Yao Y. HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/β-Catenin and BMP2 Signaling Pathways. Cell Transplant. 2019;28:1686-1699 pubmed publisher
Periasamy P, Tran V, O Neill H. Identification of genes which regulate stroma-dependent in vitro hematopoiesis. PLoS ONE. 2018;13:e0205583 pubmed publisher
Godoy J, Arrázola M, Ordenes D, Silva Alvarez C, Braidy N, Inestrosa N. Wnt-5a ligand modulates mitochondrial fission-fusion in rat hippocampal neurons. J Biol Chem. 2014;289:36179-93 pubmed publisher
Yamamoto Shiraishi Y, Kuroiwa A. Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. Dev Biol. 2013;377:363-74 pubmed publisher
Tran T, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012;287:32651-64 pubmed
Wawrzak D, Metioui M, Willems E, Hendrickx M, De Genst E, Leyns L. Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun. 2007;357:1119-23 pubmed
Canning C, Lee L, Irving C, Mason I, Jones C. Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity. Dev Biol. 2007;305:276-86 pubmed
Schmidt C, Stoeckelhuber M, McKinnell I, Putz R, Christ B, Patel K. Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation. Dev Biol. 2004;271:198-209 pubmed
Polesskaya A, Seale P, Rudnicki M. Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell. 2003;113:841-52 pubmed
product information
brand :
R&D Systems
master code :
1169-FR
SKU :
1169-FR-025
product name :
Recombinant Mouse sFRP-2 Protein
unit size :
25 ug
seo description :
The Recombinant Mouse sFRP-2 Protein from R&D Systems is derived from NS0. The Recombinant Mouse sFRP-2 Protein has been validated for the following applications: Binding Activity.
target :
sFRP-2
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
dilution :
Binding Activity
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
observed molecular weight :
35-40 kDa, reducing conditions
theoretical molecular weight :
31.6 kDa
gene symbol :
Sfrp2
details of functionality :
Measured by its ability to compete with Frizzled-1 for binding to biotinylated Wnt-3a. The IC50 value is 0.7-3.5 nM, under conditions in which Recombinant Mouse (rm) Frizzled-1 Fc Chimera (Catalog # 1120-FZ ) is present at 2.1 nM, and biotinylated rmWnt-3a concentration is 2.7 nM.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
AAB70795
applications :
Binding Activity
source :
NS0-derived Recombinant Mouse sFRP-2 Protein
USD :
498 USD
alt names :
FRP2, FRP-2secreted apoptosis related protein 1, SARP-1, SARP1sFRP-2, SDF-5, Secreted apoptosis-related protein 1, secreted frizzled-related protein 2, sFRP2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.