Recombinant Human BAFFR/TNFRSF13C Fc Chimera Protein, CF | R&D Systems 1162-BR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BAFFR/TNFRSF13C Fc Chimera Protein, CF

catalog :

1162-BR

quantity :

50 ug

price :

329 USD

citations: 4

Reference
Cao Y, Lu G, Chen X, Chen X, Guo N, Li W. BAFF is involved in the pathogenesis of IgA nephropathy by activating the TRAF6/NF‑κB signaling pathway in glomerular mesangial cells. Mol Med Rep. 2020;21:795-805 pubmed publisher
Zheng N, Wang D, Ming H, Zhang H, Yu X. BAFF promotes proliferation of human mesangial cells through interaction with BAFF-R. BMC Nephrol. 2015;16:72 pubmed publisher
Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells. Nat Immunol. 2014;15:354-364 pubmed publisher
Nishio M, Endo T, Tsukada N, Ohata J, Kitada S, Reed J, et al. Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha. Blood. 2005;106:1012-20 pubmed

product information

brand :

R&D Systems

master code :

1162-BR

SKU :

1162-BR-050

product name :

Recombinant Human BAFFR/TNFRSF13C Fc Chimera Protein, CF

description :

The Recombinant Human BAFFR/TNFRSF13C Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human BAFFR/TNFRSF13C Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

BAFFR/TNFRSF13C

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

40-50 kDa, reducing conditions

theoretical molecular weight :

33 kDa (monomer)

gene symbol :

TNFRSF13C

details of functionality :

Measured by its ability to inhibit BAFF-mediated proliferation of anti-IgM stimulated mouse B cells. Moore, P.A. et al . (1999) Science 285 :260; Gross, J.A. et al . (2000) Nature 404 :995; Schneider, P. et al . (1999) J. Exp. Med. 189 :1747. The ED50 for this effect is 20-80 ng/mL in the presence of 5 ng/mL recombinant human BAFF.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

1162-BR

accessionNumbers :

Q96RJ3

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human BAFF R/TNFRSF13C protein Human BAFF R (Ser7-Ala71) Accession # Q96RJ3 DIEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus

2020 USD :

329

2021 USD :

329 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.